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A5585

Sigma-Aldrich

5-（N-甲基-N-异丁基）阿米洛利

≥98% (TLC), powder

别名:

MIA

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About This Item

经验公式（希尔记法）:
C11H18ClN7O
CAS号:
96861-65-3
分子量:
299.76
MDL编号:
MFCD00078567
UNSPSC代码:
12352200
PubChem化学物质编号:
24278228
NACRES:
NA.77

质量水平

200

方案

≥98% (TLC)

表单

powder

mp

200-201 °C

溶解性

methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow

储存温度

2-8°C

SMILES字符串

CC(C)CN(C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

InChI

1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChI key

RVIUMPLAOXSSGN-UHFFFAOYSA-N

基因信息

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768)

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应用

5-（N-甲基-N-异丁基）阿米洛利是Na+/H+反向转运的有效阻滞剂。 5-（N-甲基-N-异丁基）阿米洛利已用于研究对酸中毒的早期细胞反应。

生化/生理作用

Na+/H+反向转运的有效阻滞剂。 可能的抗肿瘤药物。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
0000115952
0000113689
0000091870
13150404
118M4067V

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R P Maidorn et al.
British journal of cancer, 67(2), 297-303 (1993-02-01)
The extracellular pH (pHe) in solid tumours is frequently lower than the pHe in normal tissues. Cells within an acidic environment depend on mechanisms which regulate intracellular pH (pHi) for their survival, including the Na+/H+ antiport which exports protons in
X H Xiao et al.
Circulation research, 85(8), 723-730 (1999-10-16)
The role of the Na(+)/H(+) exchanger in ischemia, reperfusion, and preconditioning was investigated in isolated perfused rat hearts. Contractile function, [Na(+)](i), and pH(i) were measured; ischemic damage was assessed by the recovery of developed pressure (DP) on reperfusion. After 30
Eric Londin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(10), E1106-E1115 (2015-02-26)
Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types.
R N Kalaria et al.
Brain research. Molecular brain research, 58(1-2), 178-187 (1998-08-01)
We report the initial characterization of [3H]5-(N-methyl-N-isobutyl)amiloride (MIA) binding to the Na+/H+ exchanger (NHE) and expression of its gene in mammalian cerebrovascular, choroidal and neocortical tissues. [3H]MIA bound reversibly to particulate fractions of rat, pig and human cerebral microvessels, choroid
R M Touyz et al.
Hypertension (Dallas, Tex. : 1979), 34(3), 442-449 (1999-09-18)
This study investigated the role of the Na(+)-H+ exchanger (NHE) on angiotensin II (Ang II)-induced activation of Na(+)-dependent Mg2+ transport in vascular smooth muscle cells (VSMCs) from Wistar-Kyoto rats (WKY; n=20) and spontaneously hypertensive rats (SHR; n=20). Intracellular free concentrations
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