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Merck
CN
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文件

A4562

Sigma-Aldrich

5-(N,N-二甲基)阿米洛利 盐酸盐

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别名:
3-氨基-N-(氨基亚氨基乙基)-5-(二甲氨基)-6-氯吡嗪甲酰胺 盐酸盐, DMA
经验公式（希尔记法）:
C8H12ClN7O · HCl
CAS号:
1214-79-5
分子量:
294.14
MDL编号:
MFCD00069207
UNSPSC代码:
12352200
PubChem化学物质编号:
24278216
NACRES:
NA.77

形式

powder

质量水平

200

储存温度

2-8°C

SMILES字符串

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

InChI key

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

基因信息

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784)

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应用

5-（N,N-二甲基）阿米洛利盐酸盐是 Na 2 /H + 反式结构的选择性阻滞剂。研究了 5-（N,N-二甲基）阿米洛利盐酸盐减轻炎性疼痛的效用。

生化/生理作用

Na + /H + 反式结构的选择性阻滞剂；IC50 = 6.9 μM.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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