A4559
β-淀粉样蛋白片段 25-35
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C45H81N13O14S
化学文摘社编号:
分子量:
1060.27
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
InChI
1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)
SMILES string
CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
InChI key
WIHBNMPFWRHGDF-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
composition
Protein Content, ≥80%
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... APP(351)
General description
淀粉样蛋白β-蛋白片段 25-35 (Aβ25-35) 来源于淀粉样蛋白-β淀粉样蛋白β ，该蛋白被映射到21q21染色体上。Aβ25-35缺少N末端结构域和金属结合位点，主要是由 Aβ(1−40) 肽蛋白水解切割产生的。它具有β-折叠和 β-转角结构。
Application
淀粉样蛋白β-蛋白片段 25-35 可用于：
- 在皮质培养物中诱导神经毒性
- 诱导阿尔茨海默病′在大鼠模型中发生
- 诱导间充质干细胞(MSC)凋亡
Biochem/physiol Actions
淀粉样蛋白β-蛋白片段25-35 (Aβ25-35)参与了阿尔茨海默氏病′的发病机理。可以抑制这种转变的抑制剂可以用作控制阿尔茨海默氏病的潜在药物。它存在于阿尔茨海默氏病脑样本以及包涵体肌炎（IBM）肌肉的下丘脑和内嗅皮层神经元中。它与小胶质细胞之间存在受体结合，可以进行脂质膜插入。包含序列GSNKGAIIGLM的Aβ的功能域序列会引起神经营养作用和神经毒性作用。Aβ25-35 表现出快速聚集，显示出年龄依赖性神经毒性。
Other Notes
从0.1％TFA水溶液中冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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