生物来源
bovine liver
质量水平
形式
powder
比活
≥100 units/mg protein
组成
Protein, ≥70% biuret
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
cow ... ARG2(518752)
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一般描述
L-精氨酸酶也称为L-精氨酸氨基水解酶。它具有两种形式，如精氨酸酶-1和精氨酸酶-2。精氨酸酶1存在于肝细胞中，精氨酸酶2通常存在于肝外组织，如肾脏、大脑、骨骼肌、小肠和哺乳期乳腺。精氨酸酶-2位于人染色体14q24.1−24.3上。
生化/生理作用
L-精氨酸酶将L-精氨酸水解为L-鸟氨酸和尿素，这是排尿素物种的肝脏中尿素循环的最后一步。精氨酸酶在哺乳动物免疫系统中发挥主要作用，并且参与炎症的多个方面。
L-精氨酸酶是精氨酸的主要降解酶；它能够将精氨酸转化为鸟氨酸；缺乏该酶与痉挛和运动功能障碍有关。
单位定义
一个酶活性单位是指在pH 9.5、37 °C下，每分钟水解1.0μmol L-精氨酸所需的酶量。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Arginase: an emerging key player in the mammalian immune system
Munder M
British Journal of Pharmacology, 158(3), 638-651 (2009)
Yegnasew Takele et al.
PLoS neglected tropical diseases, 7(1), e1977-e1977 (2013-01-26)
Visceral leishmaniasis is a parasitic disease associated with high mortality. The most important foci of visceral leishmaniasis in Ethiopia are in the Northwest and are predominantly associated with high rates of HIV co-infection. Co-infection of visceral leishmaniasis patients with HIV
L-Arginase: a Medically Important Enzyme
Kumar K and Verma N
Research Journal of Pharmacy and Technology, 6(12), 1430-1430 (2013)
James W Wells et al.
PloS one, 8(1), e54464-e54464 (2013-02-01)
Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy
Eva Källberg et al.
BMC immunology, 13, 69-69 (2012-12-14)
S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function
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