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生物来源
bovine liver
质量水平
表单
powder
比活
≥100 units/mg protein
组成
Protein, ≥70% biuret
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
cow ... ARG2(518752)
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一般描述
L-精氨酸酶也称为L-精氨酸氨基水解酶。它具有两种形式,如精氨酸酶-1和精氨酸酶-2。精氨酸酶1存在于肝细胞中,精氨酸酶2通常存在于肝外组织,如肾脏、大脑、骨骼肌、小肠和哺乳期乳腺。精氨酸酶-2位于人染色体14q24.1−24.3上。
生化/生理作用
L-精氨酸酶将L-精氨酸水解为L-鸟氨酸和尿素,这是排尿素物种的肝脏中尿素循环的最后一步。精氨酸酶在哺乳动物免疫系统中发挥主要作用,并且参与炎症的多个方面。
L-精氨酸酶是精氨酸的主要降解酶;它能够将精氨酸转化为鸟氨酸。
L-精氨酸酶是精氨酸的主要降解酶;它能够将精氨酸转化为鸟氨酸;缺乏该酶与痉挛和运动功能障碍有关。
单位定义
一个酶活性单位是指在pH 9.5、37 °C下,每分钟水解1.0μmol L-精氨酸所需的酶量。
警示用语:
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
历史批次信息供参考:
Arginase: an emerging key player in the mammalian immune system
British Journal of Pharmacology, 158(3), 638-651 (2009)
L-Arginase: a Medically Important Enzyme
Research Journal of Pharmacy and Technology, 6(12), 1430-1430 (2013)
Journal of immunology (Baltimore, Md. : 1950), 190(2), 812-820 (2012-12-19)
Evaluation of immune dysfunction during the tumor-bearing state is a critical issue in combating cancer. In this study, we initially found that IL-6, one of the cachectic factors, suppressed CD4(+) T cell-mediated immunity through downregulation of MHC class II by
BMC immunology, 13, 69-69 (2012-12-14)
S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function
Methods in molecular biology (Clifton, N.J.), 946, 225-239 (2012-11-28)
Macrophages play a key role in the innate immune response and help to direct the acquired immune response. Early in the innate immune response, they produce reactive oxygen species and pro-inflammatory cytokines and chemokines to drive inflammation and are referred
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