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生物来源
synthetic
质量水平
检测方案
≥98% (TLC)
形式
powder
mp
202-205 °C (lit.)
溶解性
methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
储存温度
2-8°C
SMILES字符串
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
QDERNBXNXJCIQK-UHFFFAOYSA-N
基因信息
human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , SLC9A5(6553)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784) , Slc9a4(24785)
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应用
- 作为内皮细胞生长培养基补充剂,培养人肺微血管内皮细胞
- 加入Pluronic F-127贮备液,用于果蝇幼虫活体成像
- 加入氯化胆碱溶液,作为灌注液用于研究Na+/H+对体内空肠环路灌注的抑制作用
生化/生理作用
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I store a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
We do not have solution stability information for 5-(N-Ethyl-N-isopropyl)amiloride. The product is sensitive to light, particularly in solution. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
What can I use to make a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
We test solubility of 5-(N-Ethyl-N-isopropyl)amiloride in methanol (10 mg/mL), yielding a clear yellow solution. It is also soluble in DMSO, and in dilute aqueous acid. It is insoluble in water.
What concentration of Product A3085, 5-(N-Ethyl-N-isopropyl)amiloride, should I use in my experiment?
We have the following references for the use of 5-(N-Ethyl-N-isopropyl)amiloride. A review article mentions the use of EIPA at 1 micromolar to probe Na+ channels in rat alveolar epithelial cells; see: Matalon, S., et al., Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am. J. Physiol., 271, L1-L22 (1996). A study of the effects of EIPA on infarction in isolated rabbit hearts and cardiomyocytes has been reported; see: Sato, H., et al., The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart. Basic Res. Cardiol., 92, 339-350 (1997).
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