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文件

安全信息

A2900

Sigma-Aldrich

[Val5]-血管紧张素II 乙酸盐 水合物

≥95% (HPLC), powder

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经验公式（希尔记法）:
C49H69N13O12 · xC2H4O2 · yH2O
分子量:
1032.15 (anhydrous free base basis)
UNSPSC代码:
12352209
PubChem化学物质编号:
329770803
NACRES:
NA.77

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

组成

acetate, 1.2-10.4%

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

InChI key

INQPQDZJLFYCRH-AXOAQIBVSA-N

基因信息

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

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Amino Acid Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe

一般描述

[Val5]-血管紧张素II（[Val5]-ANG Ii）是一种含ANG II模拟物，在ANG II八肽中含有缬氨酸作为第5个氨基酸取代异亮氨酸。

应用

[Val5]-血管紧张素II醋酸盐水合物已用于诱导：
  • 小鼠肾脏损伤，以研究人肝型脂肪酸结合蛋白（hL-FABP）的作用
  • 小鼠血管炎症，以研究胞质铜伴侣抗氧化剂-1（Atox1）与肿瘤坏死因子（TNF）受体相关因子4（TRAF4）之间的相互作用
  • 小鼠腹主动脉瘤（AAA），以研究血管ATP酶铜转运α（ATP7α）的作用

生化/生理作用

[Val5]-血管紧张素II可用作血管紧张素II 1型受体（AT1受体）的激动剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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Archita Das et al.
American journal of physiology. Cell physiology, 317(6), C1161-C1171 (2019-09-26)
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cytokine TNF-α-stimulated endothelial cells (ECs), cytosolic Cu chaperone antioxidant-1 (Atox1) functions as a Cu-dependent transcription
D G Butler et al.
Archives internationales de pharmacodynamie et de therapie, 329(2), 272-282 (1995-03-01)
Pressor responses to [Ile5]-Angiotensin II and [Val5]-Angiotensin II were measured following single intravenous doses of 0.0075, 0.075, 0.375, 0.75 and 7.5 micrograms/kg b.w. in anesthetised rats. [Val5]-Angiotensin II was significantly (10 per cent) more potent than [Ile5]-angiotensin II when log
Daisuke Ichikawa et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 973-980 (2012-08-29)
To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang II and WT-Ang II) for 28 days.
Yuhan Chen et al.
Cardiovascular research, 117(4), 1217-1228 (2020-07-02)
Elevated serum immunoglobulins have been associated with experimental and human hypertension for decades but whether immunoglobulins and B cells play a causal role in hypertension pathology is unclear. In this study, we sought to determine the role of B cells
Luciana C Veiras et al.
Acta physiologica (Oxford, England), 229(1), e13448-e13448 (2020-01-30)
Sexual dimorphisms are evident along the nephron: Females (F) exhibit higher ratios of renal distal to proximal Na+ transporters' abundance, greater lithium clearance (CLi ) more rapid natriuresis in response to saline infusion and lower plasma [K+ ] vs. males
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