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A2181

Sigma-Aldrich

乙酰辅酶 A 锂盐

≥93% (HPLC)

别名:

乙酰CoA, 乙酰辅酶 A 三锂盐

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About This Item

经验公式（希尔记法）:
C23H38N7O17P3S · xLi+
CAS号:
32140-51-5
分子量:
809.57 (free acid basis)
MDL编号:
MFCD00167406
UNSPSC代码:
41106305
PubChem化学物质编号:
24890633
NACRES:
NA.51
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质量水平

300

方案

≥93% (HPLC)

表单

powder

溶解性

H2O: soluble 100 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

[Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23

InChI

1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1

InChI key

FTRFBNATWBKIQU-JHJDYNLLSA-K

基因信息

human ... CHAT(1103) , HAT1(8520) , KAT2A(2648) , KAT2B(8850) , KAT5(10524)
mouse ... HAT1(107435) , KAT2A(14534) , KAT2B(18519) , KAT5(81601)
rat ... HAT1(296501) , KAT2A(303539) , KAT2B(301164) , KAT5(192218)

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particle size

5 μm

particle size

5 μm

particle size

5 μm

particle size

5 μm

matrix

high-purity silica gel particle platform, fully porous particle

matrix

high-purity silica gel particle platform, fully porous particle

matrix

high-purity silica gel particle platform, fully porous particle

matrix

High-purity silica gel particle platform, fully porous particle

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

product line

Astec®

product line

Astec®

product line

Astec®

product line

Astec®

pore size

200 Å

pore size

200 Å

pore size

200 Å

pore size

200 Å

应用

乙酰辅酶A适用于CAT报告检测，通过将细胞提取物与0.1 μCi [14C]氯霉素和0.5mM乙酰辅酶A一起孵育来对氯霉素乙酰转移酶进行测定。[1][2][3][4]
酶催化乙酰基转移反应中必要的辅因子。

生化/生理作用

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。 它可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解而形成。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。 它也是脂质生物合成的关键前体，所有脂肪酸碳的来源。 乙酰辅酶A可正向调节丙酮酸羧化酶的活性。 它是神经递质乙酰胆碱的前体。 组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。
编码乙酰辅酶A的基因的改变已与阿尔茨海默病和轻度认知障碍存在关联。[5]该基因的缺陷可导致与阵发性呼吸暂停相关的肌无力综合征。 [6][7]

物理属性

这种湿度敏感的粉末应在−20°C下干燥储存。

制备说明

酶法制备

重悬

乙酰辅酶A可以100 mg/mL溶于去离子水。 乙酰CoA可稳定于中性和中等酸性溶液，但在碱性和强酸性溶液中会水解。 按单次使用分装的水溶液可在−20°C储存最长达两周，而在−80°C最长可达6个月。

其他说明

如需更多技术信息以及辅酶A衍生物的完整列表，请访问乙酰转移试剂资源。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000418685
    0000418685
    0000403716
    0000389832
    0000385136

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