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A2169

Sigma-Aldrich

3′-叠氮-3′-脱氧胸苷

≥98% (HPLC), powder, reverse transcriptase inhibitor

别名:

AZT, ZDV, 叠氮胸苷, 齐多夫定

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About This Item

经验公式（希尔记法）:
C10H13N5O4
CAS号:
30516-87-1
分子量:
267.24
Beilstein:
3595791
MDL编号:
MFCD00006536
UNSPSC代码:
12352200
PubChem化学物质编号:
24278143
NACRES:
NA.77

产品名称

3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)

质量水平

200

方案

≥98% (HPLC)

表单

powder

mp

113-115 °C (lit.)

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES字符串

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

基因信息

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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应用

3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。

生化/生理作用

叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H341,H351

危险分类

Carc. 2 - Muta. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Geering B, et al.
Journal of Immunological Methods, 373(1-2), 209-218 (2011)
In vitro activities of nucleoside analog antiviral agents against salmonellae.
Sperber S J, et al.
Antimicrobial Agents and Chemotherapy, 37(1), 106-110 (1993)
Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells.
Zhao, et al.
Cell discovery, 9, 45-45 (2023)
Marla E Tharp et al.
Nature communications, 11(1), 330-330 (2020-01-18)
Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking
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Neuro-oncology, 12(6), 549-558 (2010-02-16)
The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered
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