推荐产品
产品名称
N-乙酰-5-羟色胺, ≥99% (HPLC), powder
质量水平
方案
≥99% (HPLC)
表单
powder
颜色
white to faint yellow
mp
120-122 °C (lit.)
溶解性
ethanol: 50 mg/mL
储存温度
2-8°C
SMILES字符串
CC(=O)NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
InChI key
MVAWJSIDNICKHF-UHFFFAOYSA-N
基因信息
human ... MTNR1A(4543) , MTNR1B(4544)
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一般描述
N-乙酰血清素 (NAS)（又称normelatonin）是色氨酸代谢途径中褪黑激素的前体。
应用
N-乙酰基-5-羟色胺已被用于治疗神经元细胞，并分析其对Krüppel样因子15（KLF15）表达的影响。
生化/生理作用
N-乙酰血清素（NAS，又称normelatonin）可以保护神经元，因为它能够防止氧化胁迫。 它还可以抑制转录因子NF-κB的作用。NAS具有抗氧化和抗衰老作用。它可以防止β-淀粉质引起的神经毒性。它有助于维持生物膜的最佳流动性能。
褪黑激素的直接前体。它由血清素和乙酰辅酶 A 在血清素 N-乙酰转移酶（褪黑激素生物合成中的限速酶）催化下形成的。该吲哚胺是褪黑激素受体的弱激动剂，对 G 蛋白刺激和 cAMP 积累的抑制有一定的作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB
Lezoualch F, et al.
Journal of Pineal Research, 24(3), 168-178 (1998)
C S Pang et al.
Biological signals, 4(6), 311-324 (1995-11-01)
We have compared the pharmacological characteristics of 2-[125I]iodomelatonin binding to crude membrane preparations of the lung, spleen, brain and kidney of chicken. Saturation studies indicated significant differences (p < 0.05) in the equilibrium dissociation constant (Kd) and maximum number of
J K Yao et al.
Molecular psychiatry, 15(9), 938-953 (2009-04-30)
Schizophrenia is characterized by complex and dynamically interacting perturbations in multiple neurochemical systems. In the past, evidence for these alterations has been collected piecemeal, limiting our understanding of the interactions among relevant biological systems. Earlier, both hyper- and hyposerotonemia were
KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain.
Junfei Z, et al.
Biochemical and Biophysical Research Communications, 492(2), 269-274 (2017)
Jimo Borjigin et al.
Molecular and cellular endocrinology, 349(1), 13-19 (2011-07-26)
The pineal gland is a neuroendocrine organ of the brain. Its main task is to synthesize and secrete melatonin, a nocturnal hormone with diverse physiological functions. This review will focus on the central and pineal mechanisms in generation of mammalian
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