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Merck
CN
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文件

安全信息

A1755

Sigma-Aldrich

Aminophylline dihydrochloride hyderate

≥98%, powder

别名:

(Theophylline)2 · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex

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About This Item

经验公式（希尔记法）:
C7H8N4O2 · 0.5C2H8N2
CAS号:
317-34-0
分子量:
210.21
EC 号:
206-264-5
MDL编号:
MFCD00013221
UNSPSC代码:
41106305
PubChem化学物质编号:
24277691
NACRES:
NA.77

质量水平

100

检测方案

≥98%

形式

powder

颜色

white to off-white

溶解性

H2O: 50 mg/mL (solutions should be freshly prepared.)
alcohol: insoluble

储存温度

−20°C

SMILES字符串

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChI key

FQPFAHBPWDRTLU-UHFFFAOYSA-N

基因信息

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

应用

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay

生化/生理作用

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.
Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Danieli Barino Salinas et al.
Pediatric research, 87(1), 137-145 (2019-07-26)
There is a need to prognosticate the severity of cystic fibrosis (CF) detected by newborn screening (NBS) by early assessment of CF transmembrane conductance regulator (CFTR) protein function. We introduce novel instrumentation and protocol for evaluating CFTR activity as reflected
Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea
Marliana E, et al.
F1000Research (2018)
Thieu X Phan et al.
The Journal of physiology, 598(24), 5639-5659 (2020-09-19)
The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in the smooth muscle of resistance arterioles supplying skeletal muscle, heart and adipose tissue.  Activation of
Nicole M Bhave et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 14, 89-89 (2013-01-01)
Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion
Rami Doukky et al.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 19(3), 448-457 (2012-03-08)
It is unknown whether the standardized intravenous aminophylline administration following regadenoson-stress can prevent the gastrointestinal and other adverse effects associated with regadenoson. In a randomized, double-blinded, placebo-controlled clinical trial we compared the frequency and severity of regadenoson adverse effects in
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