A1439
垂体腺苷酸环化酶激活多肽-38
别名:
PACAP-38
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关于此项目
经验公式（希尔记法）:
C203H331N63O53S
化学文摘社编号:
分子量:
4534.26
UNSPSC Code:
41106305
NACRES:
NA.32
MDL number:
form
powder
composition
Peptide content, ~70%
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... ADCYAP1(116)
General description
垂体腺苷酸环化酶激活多肽38（PACAP38）定位于人类染色体18。27个残基的酰胺化片段（PACAP27）包含另一个同种型。PACAP38是与哺乳动物有关的主要同种型。
Application
垂体腺苷酸环化酶激活多肽38已用于测试其在刺激鸡的环状AMP下丘脑和大脑皮质切片形成中的作用，并在细胞迁移试验（cell migration assay）中处理胶质母细胞瘤细胞（U87MG）以测试其抗侵袭作用。
Biochem/physiol Actions
PACAP-38 是一种与血管活性肠肽 (VIP) 具有高度同源性的神经肽。 据报道，它是一种神经元存活因子。
垂体腺苷酸环化酶激活多肽38（PACAP38）是一种心脏保护剂，可有助于治疗放射诱发心脏病（RIHD）。它在心肌细胞的氧化应激过程中起保护作用。PACAP38具有抗氧化、抗细胞凋亡和抗炎特性。它与偏头痛和丛集性头痛的病理生理学有关。
Other Notes
从0.1％TFA水溶液中冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
K Tornøe et al.
American journal of physiology. Endocrinology and metabolism, 279(6), E1413-E1425 (2000-11-30)
The concentration of pituitary adenylyl cyclase-activating polypeptide [PACAP-(1-38)] in porcine adrenal glands amounted to 14 +/- 3 pmol/g tissue. PACAP immunoreactive (PACAP-IR) fibers innervated adrenal chromaffin cells (often co-localized with choline acetyltransferase). Subcapsular fibers traversed the cortex-innervating endocrine cells and
Grazia Maugeri et al.
Frontiers in pharmacology, 7, 139-139 (2016-06-16)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by extensive areas of
Huan Li et al.
American journal of translational research, 11(10), 6585-6599 (2019-11-19)
Radiation-induced heart disease (RIHD) is a common sequelae of thoracic irradiation. Currently, there is no effective prevention and treatment strategy. Oxidative stress is associated with the development of RIHD. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) has been defined as the
Bernadett Tuka et al.
The journal of headache and pain, 17(1), 69-69 (2016-08-01)
Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and
Eloisa Rubio-Beltrán et al.
The journal of headache and pain, 19(1), 64-64 (2018-08-09)
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated.Migraine is a neurovascular
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