A143
(S)-(−)-Atenolol
powder
别名:
(−)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
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关于此项目
线性分子式:
(CH3)2CHNHCH2CH(OH)CH2OC6H4CH2CONH2
化学文摘社编号:
分子量:
266.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
(S)-(−)-Atenolol, powder
InChI
1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m0/s1
SMILES string
CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1
InChI key
METKIMKYRPQLGS-LBPRGKRZSA-N
form
powder
optical activity
[α]23/D −10.5°, c = 0.5 in H2O(lit.)
color
white to beige
mp
148-152 °C (lit.)
solubility
0.1 M HCl: soluble
Quality Level
Gene Information
human ... ADRB1(153)
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Application
(S)-(-)-Atenolol may be used as a standard in the preparation of enantiomer for high-performance liquid chromatography-tandem mass spectrometry studies (HPLC-MS/MS). It has also been used in the β blocking molecule for Raman spectroscopy studies.
Biochem/physiol Actions
(S)-(-)-Atenolol is a β1-adrenergic receptor antagonist and an active enantiomer of atenolol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
The influence of molecular structure modifications on vibrational properties of some beta blockers: a combined raman and DFT study
Farca? A, et al.
Journal of Spectroscopy (New York, NY, United States) (2016)
A A Pearson et al.
The Journal of pharmacology and experimental therapeutics, 250(3), 759-763 (1989-09-01)
Previous studies have demonstrated that propranolol can lower arterial pressure through an action within the central nervous system. The purpose of this study was to determine 1) whether the hydrophilic beta blocking drug atenolol which is devoid of membrane stabilizing
Kevin F Morris et al.
Chemical physics, 457, 133-146 (2015-08-11)
Molecular dynamics simulations and NMR spectroscopy were used to compare the binding of two β-blocker drugs to the chiral molecular micelle poly-(sodium undecyl-(L)-leucine-valine). The molecular micelle is used as a chiral selector in capillary electrophoresis. This study is part of
S A Doggrell
Chirality, 5(1), 8-14 (1993-01-01)
The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol alone on the rat left atria and portal vein and on the respective beta 1- and beta 2-adrenoceptor-mediated responses to isoprenaline have been determined. (+/-)-Atenolol at 10(-6) M had no
Ulisse Garbin et al.
Mediators of inflammation, 2008, 367590-367590 (2008-04-26)
The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare the effects of two beta blockers such as nebivolol and
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