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安全信息

A1086

Sigma-Aldrich

N-乙酰基-Asp-Glu-Val-Asp-7-酰胺基-4-甲基香豆素

≥97% (HPLC), powder

别名:

Ac-DEVD-AMC

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About This Item

经验公式（希尔记法）:
C30H37N5O13
CAS号:
169332-61-0
分子量:
675.64
MDL编号:
MFCD00671411
UNSPSC代码:
12352209
PubChem化学物质编号:
24890505
NACRES:
NA.77

质量水平

100

检测方案

≥97% (HPLC)

形式

powder

组成

Peptide content, ~65%

颜色

white

溶解性

DMSO: 10 mM

储存温度

−20°C

SMILES字符串

CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1

InChI key

ALZSTTDFHZHSCA-RNVDEAKXSA-N

应用

N-乙酰基-Asp-Glu-Val-Asp-7-酰胺基-4-甲基香豆素已被用作人结肠癌细胞系和骨髓间充质干细胞中caspase-3检测的底物。

生化/生理作用

caspase 3的荧光底物，而caspase 3是一种当细胞暴露于凋亡条件下时会被快速激活并裂解聚（ADP-核糖）聚合酶的蛋白酶。

特点和优势

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面，请点击此处。
这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

相关产品

产品编号
说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Alice Dreser et al.
Cell death and differentiation, 24(10), 1655-1671 (2017-06-18)
Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons (MNs) and their target muscles. Misfolded proteins which often form intracellular aggregates are a pathological hallmark of ALS. Disruption of the functional interplay between protein degradation (ubiquitin
Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells
Classen F, et al.
Experimental Cell Research, 374(1), 29-37 (2018)
Ciaran Lawlor et al.
PloS one, 11(2), e0149167-e0149167 (2016-02-20)
The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has increased the urgency to develop novel treatment modalities, and inhalable microparticle (MP) formulations are a promising option to target
Yi-Xin Wu et al.
Oncotarget, 7(47), 77622-77634 (2016-10-22)
Bortezomib (BTZ), a proteasome inhibitor, is the first proteasome inhibitor to be used in clinical practice. Here we investigated the mechanisms underlying acquired bortezomib resistance in hepatocellular carcinoma (HCC) cells. Using stepwise selection, we established two acquired bortezomib-resistant HCC cell
Saravana P Selvanathan et al.
Nucleic acids research, 47(18), 9619-9636 (2019-08-09)
Connections between epigenetic reprogramming and transcription or splicing create novel mechanistic networks that can be targeted with tailored therapies. Multiple subunits of the chromatin remodeling BAF complex, including ARID1A, play a role in oncogenesis, either as tumor suppressors or oncogenes.
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