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安全信息

A1075

Sigma-Aldrich

淀粉样蛋白β蛋白片段1-40

≥90% (HPLC), powder

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别名:
Aβ40
经验公式（希尔记法）:
C194H295N53O58S
CAS号:
131438-79-4
分子量:
4329.80
MDL编号:
MFCD00130509
UNSPSC代码:
12352202
NACRES:
NA.32

质量水平

200

检测方案

≥90% (HPLC)

形式

powder

颜色

white

溶解性

1% acetic acid: 1 mg/mL
saline: insoluble

UniProt登记号

P05067

储存温度

−20°C

基因信息

human ... APP(351)

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Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

一般描述

淀粉样β蛋白片段1-40 (Aβ40)来源于淀粉样-β蛋白(Aβ)，对应于人类21q21.3染色体。Aβ40主要存在于血管淀粉样蛋白沉积物中。Aβ40包含C端膜插入结构域。其可揭示水胶束介质中从无规卷曲结构到α-螺旋结构的结构转变。

应用

淀粉样β蛋白片段1-40已用于：
  • 基于温度的构象研究，采用傅里叶变换红外/差分扫描量热法（FT-IR/DSC）开展研究
  • 用作夹心式酶促免疫测定的参考标准品，以定量头部外伤患者脑脊髓液中的淀粉样蛋白A4
  • 用作胚胎干细胞培养基组分，抑制成纤维细胞淀粉样蛋白沉积

生化/生理作用

淀粉样β蛋白片段1-40 (Aβ40)可形成基于阳离子的离子通道。
淀粉质 β-蛋白是神经营养性的，但在人和大鼠神经细胞 体内和体外培养中是有神经毒性的。 β-淀粉质多肽（氨基酸1-42和1-43）是爱尔兹海默′s 病人海马，新皮质和杏仁核中老年斑和神经原纤维结的主要组成部分。

重悬

为了保证最大的生物活性，用无钙PBS中稀释至1mg/ml保存，在37℃培养4天。

其他说明

从0.1％TFA水溶液中冻干

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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M Citron et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(23), 13170-13175 (1996-11-12)
Cerebral deposition of the amyloid beta protein (A beta) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of A beta (A beta 40) accounts for approximately 90% of all A beta normally released
D R Howlett et al.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 4(1), 23-32 (1995-03-01)
The behaviour of synthetic batches of beta-amyloid (beta A) 1-40 peptide in solution has been studied. The effects of beta A1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the
H Funato et al.
The American journal of pathology, 152(4), 983-992 (1998-04-18)
Amyloid beta-protein (Abeta) is the major component of senile plaques that emerge in the cortex during aging and appear most abundantly in Alzheimer's disease. In the course of our immunocytochemical study on a large number of autopsy cases, we noticed
Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Mehta PD, et al.
Neuroscience Letters, 304(1-2), 102-106 (2001)
K Ueda et al.
Brain research, 639(2), 240-244 (1994-03-14)
The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (A beta P) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, aggregated beta(1-40)
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