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A1075

Sigma-Aldrich

淀粉样蛋白β蛋白片段1-40

≥90% (HPLC), powder

别名:

Aβ40

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About This Item

经验公式（希尔记法）:
C194H295N53O58S
CAS号:
131438-79-4
分子量:
4329.80
MDL编号:
MFCD00130509
UNSPSC代码:
12352202
NACRES:
NA.32

质量水平

200

方案

≥90% (HPLC)

表单

powder

颜色

white

溶解性

1% acetic acid: 1 mg/mL
saline: insoluble

UniProt登记号

P05067

储存温度

−20°C

基因信息

human ... APP(351)

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Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

一般描述

淀粉样β蛋白片段1-40 (Aβ40)来源于淀粉样-β蛋白(Aβ)，对应于人类21q21.3染色体。Aβ40主要存在于血管淀粉样蛋白沉积物中。Aβ40包含C端膜插入结构域。其可揭示水胶束介质中从无规卷曲结构到α-螺旋结构的结构转变。

应用

淀粉样β蛋白片段1-40已用于：
  • 基于温度的构象研究，采用傅里叶变换红外/差分扫描量热法（FT-IR/DSC）开展研究
  • 用作夹心式酶促免疫测定的参考标准品，以定量头部外伤患者脑脊髓液中的淀粉样蛋白A4
  • 用作胚胎干细胞培养基组分，抑制成纤维细胞淀粉样蛋白沉积

生化/生理作用

淀粉样β蛋白片段1-40 (Aβ40)可形成基于阳离子的离子通道。
淀粉质 β-蛋白是神经营养性的，但在人和大鼠神经细胞 体内和体外培养中是有神经毒性的。 β-淀粉质多肽（氨基酸1-42和1-43）是爱尔兹海默′s 病人海马，新皮质和杏仁核中老年斑和神经原纤维结的主要组成部分。

重悬

为了保证最大的生物活性，用无钙PBS中稀释至1mg/ml保存，在37℃培养4天。

其他说明

从0.1％TFA水溶液中冻干

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000327696
0000327696
0000198949
0000198948
0000198949

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. This product has a temperature storage of -20 C on the label, but the material did not come on ice. Is the product still good?

    Where there may short-term exposure (I.e. during shipment) to conditions other than those recommended for long-term storage that will not affect product quality, Sigma-Aldrich will ship at ambient temperature.

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Diversity of amyloid beta protein fragment [1-40]-formed channels
Kourie JI, et al.
Cellular and Molecular Neurobiology, 21(3), 255-284 (2001)
Xujiao Huang et al.
Molecular medicine reports, 16(3), 2700-2706 (2017-07-18)
Alzheimer's disease (AD) is the most common type of senile dementia, which often develops in elderly or presenile individuals. As one of the pathological features of AD, amyloid β‑protein (Aβ) causes energy dysmetabolism, thereby inducing cellular damage and apoptosis. Salidroside
Temperature-induced conformational changes in amyloid beta (1-40) peptide investigated by simultaneous FT-IR microspectroscopy with thermal system
Chu HL and Lin SY
Biophysical Chemistry, 89(2-3), 173-180 (2001)
Charlotte E Teunissen et al.
Journal of Alzheimer's disease : JAD, 62(4), 1857-1863 (2018-04-05)
The 42 amino acid form of amyloid-β (Aβ42) plays a key role in the pathogenesis of Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ42 concentrations are
Sandwich-Type Enzyme Immunoassay for Amyloid A4 Protein in Cerebrospinal Fluid From Patients with Head Trauma
PIRIM I
Turkish Journal of Medical Sciences, 31(1), 47-50 (2001)
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