A0835
N-Acetyl-Asp-Glu-Val-Asp-al
≥95%, powder
别名:
Ac-DEVD-CHO
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H30N4O11
化学文摘社编号:
分子量:
502.47
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
产品名称
N-Acetyl-Asp-Glu-Val-Asp-al, ≥95%, powder
InChI
1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)
SMILES string
[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
InChI key
UMBVAPCONCILTL-UHFFFAOYSA-N
biological source
synthetic
assay
≥95%
form
powder
color
white
solubility
H2O: 1 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)
Application
N-Acetyl-Asp-Glu-Val-Asp-al已在肌肉样品、平滑肌细胞和Jurkat T细胞中被用作半胱氨酸蛋白酶抑制剂。
Biochem/physiol Actions
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 可通过其半胱氨酸蛋白酶抑制剂的功能性有助于顿抑心肌的恢复。
IL-1β的可逆性抑制剂；转化酶（ICE）；通过凋亡蛋白（caspase 3）抑制聚（ADP-核糖）聚合酶的切割。
General description
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 是一种具有N端乙酰化和C端醛共轭的四肽。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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