A0788
3-氨基苯甲酰胺
≥99% (TLC), PARP inhibitor, powder
别名:
3-AB, 3-ABA
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关于此项目
线性分子式:
H2NC6H4CONH2
化学文摘社编号:
分子量:
136.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
222-586-9
MDL number:
产品名称
3-氨基苯甲酰胺, ≥99% (TLC)
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
SMILES string
NC(=O)c1cccc(N)c1
assay
≥99% (TLC)
form
powder
color
white to off-white
mp
115-116 °C (lit.)
solubility
ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)
storage temp.
room temp
Quality Level
Gene Information
mouse ... Parp1(11545)
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Application
3-氨基苯甲酰胺已用作多种实验研究中的多聚（ADP-核糖）聚合酶(PARP)抑制剂。
Biochem/physiol Actions
3-氨基苯甲酰胺可干扰电离辐射和几种烷基化试剂诱发的DNA链断裂损伤修复，导致细胞死亡、程序外DNA合成和修复复制增加。它可抑制核酶多聚（ADP-核糖）合成酶(PARS)的活性。3-氨基苯甲酰胺具有抵抗心肌再灌注损伤和局部炎症的保护作用。
Features and Benefits
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts
Morgan W and Cleaver J
Cancer Research, 43(7), 3104-3107 (1983)
Cheng Wang et al.
Nature communications, 10(1), 1203-1203 (2019-03-15)
Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models. Here we show that PARP activity is increased in radial
BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
Beauchamp M, et al.
Gynecologic Oncology, 115(2), 193-198 (2009)
Feyza Ademoğlu et al.
Pharmacology, 66(1), 1-4 (2002-08-10)
We have previously reported that peroxynitrite (ONOO(-)) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO(-) (0.03- 1.0 mmol/l)-induced relaxations were reduced significantly by the presence of
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
Zingarelli B, et al.
Cardiovascular Research, 36(2), 205-215 (1997)
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