检测方案
≥99% (TLC)
形式
powder
颜色
white to off-white
mp
115-116 °C (lit.)
溶解性
ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)
储存温度
room temp
SMILES字符串
NC(=O)c1cccc(N)c1
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
基因信息
mouse ... Parp1(11545)
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应用
3-氨基苯甲酰胺已用作多种实验研究中的多聚（ADP-核糖）聚合酶(PARP)抑制剂。
生化/生理作用
3-氨基苯甲酰胺可干扰电离辐射和几种烷基化试剂诱发的DNA链断裂损伤修复，导致细胞死亡、程序外DNA合成和修复复制增加。它可抑制核酶多聚（ADP-核糖）合成酶(PARS)的活性。3-氨基苯甲酰胺具有抵抗心肌再灌注损伤和局部炎症的保护作用。
特点和优势
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts
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BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
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An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications
Decker P, et al.
Clinical Cancer Research, 5(5), 1169-1172 (1999)
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