A0466
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin
≥90% (HPLC), powder
别名:
Ac-DEVD-AFC
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C30H34F3N5O13
化学文摘社编号:
分子量:
729.61
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
产品名称
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin, ≥90% (HPLC), powder
InChI
1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI key
GZDRODOYEFEHGG-NUDCOPPTSA-N
assay
≥90% (HPLC)
form
powder
color
white
solubility
H2O: 1 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... CASP3(836)
Biochem/physiol Actions
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
A fluorogenic substrate for caspase 3; has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Konduru S Sastry et al.
Cell death & disease, 8(6), e2844-e2844 (2017-06-02)
Cancer stem cells (CSCs) are increasingly considered to be responsible for tumor initiation, metastasis and drug resistance. The drug resistance mechanisms activated in CSCs have not been thoroughly investigated. Although neuropeptides such as vasoactive intestinal peptide (VIP) can promote tumor
Mélodie Grandin et al.
EMBO molecular medicine, 8(8), 863-877 (2016-07-06)
In a number of human cancers, NTN1 upregulation inhibits apoptosis induced by its so-called dependence receptors DCC and UNC5H, thus promoting tumor progression. In other cancers however, the selective inhibition of this dependence receptor death pathway relies on the silencing
Elisabetta Gabano et al.
Dalton transactions (Cambridge, England : 2003), 46(41), 14174-14185 (2017-10-07)
The design, synthesis, characterization and biological properties of a Pt(iv) complex containing the very active inhibitor of histone deacetylase (2-propynyl)octanoic acid, POA, as an axial ligand are reported here. The title complex, namely (OC-6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(iv), 1, containing POA in racemic or
Kazuki Akazawa et al.
Bioconjugate chemistry, 29(5), 1720-1728 (2018-05-02)
Highly sensitive imaging of enzymatic activities in the deep tissues of living mammals provides useful information about their biological functions and for developing new drugs; however, such imaging is challenging. 19F magnetic resonance imaging (MRI) is suitable for noninvasive visualization
Aditya D Joshi et al.
Molecular pharmacology, 92(3), 366-374 (2017-07-12)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a plethora of target genes. Historically, the AhR has been studied as a regulator of xenobiotic metabolizing enzyme genes, notably cytochrome P4501A1 encoded by CYP1A1, in response to
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持