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A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

别名:

ACTH4-10

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关于此项目

经验公式（希尔记法）:
C44H59N13O10S
化学文摘社编号:
4037-01-8
分子量:
962.09
UNSPSC Code:
12352202
PubChem Substance ID:
24890423
NACRES:
NA.26
MDL number:
MFCD00167482
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产品名称

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189, P47866

storage temp.

−20°C

SMILES string

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Crhr2(64680)

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Lacks adrenocorticotropic activity.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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