A0384
魁蛤素 硫酸盐
别名:
1,4-双胍基丁烷 硫酸盐
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关于此项目
经验公式（希尔记法）:
C6H16N6 · H2O4S
化学文摘社编号:
分子量:
270.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
InChI key
RWTGFMPOODRXIM-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
mp
>280 °C
solubility
1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Quality Level
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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相关类别
Application
Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
- to evaluate its effects on the acquisition of electrical kindling of the amygdala
- to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
- to study its effects on cell-free translation of synthetic polynucleotide
Biochem/physiol Actions
Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Nádia Aléssio Velloso Bellé et al.
Brain research, 1008(2), 245-251 (2004-05-18)
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the
Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.
I J Reynolds
European journal of pharmacology, 177(3), 215-216 (1990-02-27)
R C Araneda et al.
Biophysical journal, 76(6), 2899-2911 (1999-06-04)
Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors. Polyamine block of NMDA receptors was studied in excised outside-out patches from rat hippocampal neurons and Xenopus oocytes expressing recombinant receptors. Extracellular spermine and arcaine
Anne Baron et al.
Neuropharmacology, 94, 19-35 (2015-01-24)
Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has become a key challenge to study their structure, their molecular and cellular functions and their physiopathological roles. This review provides a summary of the different compounds that directly interact with
Koichi Tan-No et al.
Pain, 113(3), 301-309 (2005-01-22)
Intrathecal (i.t.) administration into mice of N-ethylmaleimide (NEM), a cysteine protease inhibitor, produced a characteristic behavioral response, the biting and/or licking of the hindpaw and the tail along with slight hindlimb scratching directed toward the flank. The behavior induced by
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