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安全信息

A0257

Sigma-Aldrich

阿托品 硫酸盐 一水合物

≥97% (TLC), crystalline, cholinergic receptor antagonist

别名:

(8-甲基-8-氮杂双环[3.2.1]辛-3-基) edno-(+/-)-α-(羟甲基)苯乙酸酯, 龙葵碱

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About This Item

线性分子式:
(C17H23NO3)2 · H2SO4 · H2O
CAS号:
5908-99-6
分子量:
694.83
Beilstein:
6109275
EC 号:
200-235-0
MDL编号:
MFCD00074815
UNSPSC代码:
12352210
PubChem化学物质编号:
57653815
NACRES:
NA.32

产品名称

阿托品 硫酸盐 一水合物, ≥97% (TLC), crystalline

质量水平

200

方案

≥97% (TLC)

表单

crystalline

颜色

white

mp

189-192 °C (A) (lit.)

溶解性

H2O: 2.5 g/mL (stable for several days at 4 °C.)
ethanol: 200 mg/mL (stable for several days at 4 °C.)
glycerol: 400 mg/mL (stable for several days at 4 °C.)

SMILES字符串

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

基因信息

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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一般描述

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

应用

Atropine sulfate salt hydrate has been used:
  • to assay specific binding of high-affinity 3-quinuclidinyl benzilate-3H ([3H]QNB) to the muscarinic acetylcholine receptor (mAChR)
  • to block the recovery phase of the aldicarb (Ald) response
  • as an analyte for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • as a mAChR antagonist to block acetylcholine receptor

生化/生理作用

位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF5209V
WXBF1811V
BCCJ0141
BCCG8993
BCCC3578

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Wikeckowska A, et al.
Journal of Neurochemistry, 147(3), 361-379 (2018)
Faust's Anesthesiology Review E-Book (2014)
Method validation for simultaneous determination of atropine, pralidoxime and 12 organophosphorus compounds in blood samples by means of high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
<BIG>Marques GLM, et al</BIG>.
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Chromatograms

application for HPLC

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