product name
Z-VAD-FMK, solid
生物来源
synthetic
质量水平
检测方案
≥98% (TLC)
形式
solid
颜色
white
溶解性
DMSO: 20 mg/mL
H2O: insoluble
储存温度
−20°C
InChI
1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI key
MIFGOLAMNLSLGH-QOKNQOGYSA-N
基因信息
human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)
一般描述
Z-VAD-FMK抑制酵母和哺乳动物肽_N_-聚糖酶(PNGase)。[1]它可以阻断细胞凋亡。Z-VAD-FMK可能与内质网(ER)应激有关。
应用
Z-VAD-FMK 可用于:
- 诱导L929细胞中的混合谱系激酶结构域样(MLKL)磷酸化(p-MLKL)
- 在Jurkat和K562细胞中诱导自噬
- 恢复奥沙利铂或奥沙利铂联合氯喹(CQ)对HCT116和SW620细胞系的杀伤作用
- 作为半胱天冬酶抑制剂,抑制细胞凋亡并评估核因子-kB、热休克蛋白70(Hsp 70)、原癌基因(cmyc)和肿瘤抑制蛋白
生化/生理作用
半胱天冬酶-1和半胱天冬酶-3相关蛋白酶的非选择性、细胞渗透性抑制剂。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处 ,查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm。
包装
无底玻璃瓶。内容物在插入式融锥内。
注意
吸湿
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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商品
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