所有图片(1)
别名:
N,N-二甲基-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-（乙酰氧基）-3-乙烯基十二氢-10,10b-二羟基-3,4a,7,7,10a-五甲基-1-氧代-1H-萘 [2,1-b] 吡喃-6-基酯 b-丙氨酸 盐酸盐, 甲磺酸可福新 盐酸盐, 福斯可林
经验公式（希尔记法）:
C27H43NO8·HCl
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 3 mg/mL, clear to slightly hazy (warmed)
储存温度
2-8°C
SMILES字符串
Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C
InChI
1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChI key
VIRRLEDAYYYTOD-YHEOSNBFSA-N
生化/生理作用
NKH 477是一种有效的口服活性腺苷酸环化酶激活剂。它是毛喉素的水溶性衍生物，剂量依赖性基团可以增加cAMP并阻断钾诱导的平滑肌条收缩收缩（IC50 = 80 nM）。NKH 477导致组胺处理的豚鼠平滑肌变得松弛（IC50 = 32 nM）。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
制备说明
可能出现澄清至轻微浑浊溶液。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mika Takarada-Iemata et al.
Journal of neurochemistry, 130(3), 374-387 (2014-04-05)
N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation- and stress-associated molecule predominantly expressed in astrocytes in the CNS. In this study, we examined the expression and the role of Ndrg2 after cortical stab injury. We observed that Ndrg2 expression was
Mika Shirasu et al.
Neuron, 81(1), 165-178 (2013-12-24)
Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various
Li-Hua Hang et al.
Pharmacological reports : PR, 65(3), 710-716 (2013-08-21)
It has been shown that spinal PKA/CREB signaling pathway is involved in neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously been investigated. The aim of this study was to examine the potential role of
Saw Marlar et al.
American journal of physiology. Cell physiology, 306(6), C598-C606 (2014-01-24)
Regulated urine concentration takes place in the renal collecting duct upon arginine vasopressin (AVP) stimulation, where subapical vesicles containing aquaporin-2 (AQP2) are inserted into the apical membrane instantly increasing water reabsorption and urine concentration. The reabsorped water exits via basolateral
Chin-San Loo et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17119-17124 (2013-10-03)
In kidney collecting duct cells, filamentous actin (F-actin) depolymerization is a critical step in vasopressin-induced trafficking of aquaporin-2 to the apical plasma membrane. However, the molecular components of this response are largely unknown. Using stable isotope-based quantitative protein mass spectrometry
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门