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Merck
CN

N3290

NKH 477

≥98% (HPLC), powder, adenylyl cyclase activator

别名:

N,N-二甲基-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-（乙酰氧基）-3-乙烯基十二氢-10,10b-二羟基-3,4a,7,7,10a-五甲基-1-氧代-1H-萘 [2,1-b] 吡喃-6-基酯 b-丙氨酸 盐酸盐, 甲磺酸可福新 盐酸盐, 福斯可林

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关于此项目

经验公式（希尔记法）:
C27H43NO8·HCl
化学文摘社编号:
138605-00-2
分子量:
546.09
UNSPSC Code:
12352200
PubChem Substance ID:
329818606
NACRES:
NA.77
MDL number:
MFCD00236421

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产品名称

NKH 477, ≥98% (HPLC), powder

SMILES string

Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C

InChI key

VIRRLEDAYYYTOD-YHEOSNBFSA-N

InChI

1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 3 mg/mL, clear to slightly hazy (warmed)

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

NKH 477是一种有效的口服活性腺苷酸环化酶激活剂。
NKH 477是一种有效的口服活性腺苷酸环化酶激活剂。它是毛喉素的水溶性衍生物，剂量依赖性基团可以增加cAMP并阻断钾诱导的平滑肌条收缩收缩（IC50 = 80 nM）。NKH 477导致组胺处理的豚鼠平滑肌变得松弛（IC50 = 32 nM）。

Features and Benefits

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

Preparation Note

可能出现澄清至轻微浑浊溶液。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000494375
0000494375
0000396626
0000396659
0000392627

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