M4910
1-甲基组胺 二盐酸盐
≥98% (TLC), powder
别名:
1-甲基-4-（β-氨基乙基）咪唑 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H11N3 · 2HCl
化学文摘社编号:
分子量:
198.09
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
1-甲基组胺 二盐酸盐, ≥98% (TLC), powder
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
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Application
本品（1-甲基组胺二盐酸）可作为标准品，用于通过液相色谱法检测青光眼患者房水中的组氨酸浓度。也可用作胺氧化酶的活性检测底物。
Biochem/physiol Actions
1-甲基组胺存在于大脑中，是由组胺N-甲基转移酶催化组胺生成的代谢产物。它可作为阿尔茨海默病(AD)、睡眠过度等神经疾病患者脑脊液中组胺能神经系统活性的生物标志物。
通过组胺N-甲基转移酶产生的组胺的主要代谢产物。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
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The Journal of pharmacology and experimental therapeutics, 334(3), 945-954 (2010-06-10)
We previously suggested that therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). However, H(3)Rs exhibit constitutive activity, and most H(3)R antagonists act as inverse agonists. Here, we have investigated the effects
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British journal of pharmacology, 99(4), 637-642 (1990-04-01)
1. The antagonistic actions of parafluorohexahydrosiladiphenidol (pFHHSiD) at muscarinic receptors has been studied in cardiac muscle, smooth muscle and cell culture preparations. In this paper, the classification scheme of Doods et al. (1987) is employed. This scheme is based upon
A Burban et al.
The Journal of pharmacology and experimental therapeutics, 332(3), 912-921 (2009-12-17)
Histamine potentiates activation of native and recombinant N-methyl-d-aspartate receptors (NMDARs), but its mechanisms of action and physiological functions in the brain remain controversial. Using four different models, we have further investigated the histamine-induced potentiation of various NMDAR-mediated responses. In single
Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population.
S Winterkamp et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S57-S58 (2003-05-21)
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