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L9908

Sigma-Aldrich

LY-294,002 盐酸盐

solid, ≥98% (HPLC)

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别名:
2-(4-吗啉基)-8-苯基-1(4H)-苯并吡喃-4-酮 盐酸盐
经验公式（希尔记法）:
C19H17NO3 · HCl
CAS号:
934389-88-5
分子量:
343.80
MDL编号:
MFCD00270881
UNSPSC代码:
12352207
PubChem化学物质编号:
24278828
NACRES:
NA.77

生物来源

microbial (Staphylococcus roseus)

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

DMSO: >5 mg/mL
H2O: insoluble

储存温度

2-8°C

SMILES字符串

O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

InChI key

CZQHHVNHHHRRDU-UHFFFAOYSA-N

相关类别

一般描述

LY-294,002盐酸盐是类黄酮化合物槲皮素的衍生物，可引发对磷酸肌醇3-激酶（PI3K）的更高抑制。LY-294,002可抑制巨噬细胞的核因子κB信号传导。它可以提高自噬体蛋白LC3的表达，并促进胃癌 和鼻咽癌细胞的凋亡。LY-294,002可调节动作电位复极化并改善肌细胞收缩性。

应用

LY-294,002盐酸盐已被用于抑制：
  • 人肺癌细胞中的磷酸肌醇3-激酶（PI3K）
  • 间充质干细胞（MSCs）的自噬。
  • 成纤维细胞 心肌细胞中的丝氨酸/苏氨酸特异性蛋白激酶（AKT）信号传导。

生化/生理作用

磷脂酰肌醇3-激酶的特异性细胞渗透性抑制剂。

特点和优势

《受体分类和信号转导》手册的G蛋白质（异三聚体）和磷酸肌醇激酶页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸和激酶磷酸酶生物学研究的特色产品。发现更多环核苷酸和激酶磷酸酶生物学特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?

    After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.

  4. What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?

    One can use this product at 50 uM concentration.

  5. Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?

    Sigma-Aldrich has not done any such testing, but the following references may be helpful: Phosphatidylinositol 3´-Kinase Is a Critical Mediator of Interferon-γ-Induced Increases in Enteric Epithelial Permeability E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils Activation of Phosphoinositide 3´-kinase in Response to High Glucose Leads to Regulation of Reactive Oxygen Species Related Nuclear Factor-κB Activation and Cyclooxygenase-2 Expression in Mesangial Cells

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway
Liu X, et al.
Journal of the American Heart Association, 7(13), e008654-e008654 (2018)
miR-126 suppresses epithelial-to-mesenchymal transition and metastasis by targeting PI3K/AKT/Snail signaling of lung cancer cells
Jia Z, et al.
Oncology Letters, 15(5), 7369-7375 (2018)
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
Walker EH, et al.
Molecular Cell, 6(4), 909-919 (2000)
G J Brunn et al.
The EMBO journal, 15(19), 5256-5267 (1996-10-01)
The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR is similar to those of mammalian and yeast phosphatidylinositol (PI) 3-kinases. This study
C J Vlahos et al.
Journal of immunology (Baltimore, Md. : 1950), 154(5), 2413-2422 (1995-03-01)
Neutrophils contain a multicomponent NADPH oxidase system that is involved in the production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP activates this respiratory burst enzyme to produce superoxide and also has been shown to result in
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