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ED4SS

Sigma-Aldrich

乙二胺四乙酸 四钠盐 二水合物

99.0-102.0% (titration)

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别名:
EDTA 四钠盐, 乙二胺四乙酸四钠盐 二水合物, 依地酸钙钠
线性分子式:
(NaOOCCH2)2NCH2CH2N(CH2COONa)2 · 2H2O
CAS号:
10378-23-1
分子量:
416.20
Beilstein:
3861753
EC 号:
200-573-9
MDL编号:
MFCD00150026
UNSPSC代码:
12352202
PubChem化学物质编号:
24894711
NACRES:
NA.77

质量水平

300

检测方案

99.0-102.0% (titration)

形式

crystalline

反应适用性

reagent type: chelator

溶解性

H2O: soluble, clear, colorless

SMILES字符串

O.O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.4Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;2*1H2/q;4*+1;;/p-4

InChI key

KSYNLCYTMRMCGG-UHFFFAOYSA-J

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相关类别

一般描述

乙二胺四乙酸(EDTA)是一种多元酸，用作金属螯合剂。由4个羧基和2个氨基组成，孤对电子可螯合钙等多种金属离子。 

应用

乙二胺四乙酸四钠盐二水合物已用于：
  • 使股骨脱钙，用于骨软骨组织的组织处理和染色
  • 作为NH4Cl裂解缓冲液组分，用于红细胞裂解和整体鉴定
  • 分离小鼠结缔组织隐窝

生化/生理作用

乙二胺四乙酸(EDTA)可治疗重金属离子中毒患者。EDTA可抑制金属蛋白酶活性位点的锌离子，也可抑制其他金属离子依赖性蛋白酶，如钙依赖性半胱氨酸蛋白酶。EDTA可能会干扰金属依赖性生物学过程。EDTA可抑制血小板聚集，并且是血小板计数最常用的抗凝剂。EDTA可联合其他活性试剂抑制微生物和生物膜，例如柠檬酸、醇、抗生素、聚六亚甲基双胍(PHMB)季铵等消毒剂。EDTA可用作血液学检验的抗凝剂，稳定血细胞的细胞组分和形态。 
乙二胺四乙酸(EDTA)用于消除痕量重金属对酶的抑制作用，并抑制需要二价阳离子作为辅因子的酶。

警示用语：

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2

靶器官

Respiratory Tract

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Palaniappan Sethu et al.
Analytical chemistry, 76(21), 6247-6253 (2004-11-02)
Leukocyte isolation from whole blood to study inflammation requires the removal of contaminating erythrocytes. Leukocytes, however, are sensitive to prolonged exposure to hyper/hypoosmotic solutions, temperature changes, mechanical manipulation, and gradient centrifugation. Even though care is taken to minimize leukocyte activation
A Chevrier et al.
Osteoarthritis and cartilage, 15(3), 316-327 (2006-09-30)
Marrow-stimulation techniques are used by surgeons to repair cartilage lesions although consistent regeneration of hyaline cartilage is rare. We have shown previously that autologous blood can be mixed with a polymer solution containing chitosan in a glycerol phosphate (GP) buffer
Giuseppe Banfi et al.
Clinical chemistry and laboratory medicine, 45(5), 565-576 (2007-05-09)
Anticoagulants are used to prevent clot formation both in vitro and in vivo. In the specific field of in vitro diagnostics, anticoagulants are commonly added to collection tubes either to maintain blood in the fluid state for hematological testing or
Geoffroy Goujon et al.
Advanced healthcare materials, 10(11), e2100059-e2100059 (2021-04-24)
Oxidative stress, which is one of the main harmful mechanisms of pathologies including ischemic stroke, contributes to both neurons and endothelial cell damages, leading to vascular lesions. Although many antioxidants are tested in preclinical studies, no treatment is currently available
Michael L Salinas et al.
Biophysical journal, 118(4), 885-897 (2019-10-22)
The increasing prevalence of adult and adolescent obesity and its associated risk of colorectal cancer reinforces the urgent need to elucidate the underlying mechanisms contributing to the promotion of colon cancer in obese individuals. Adiponectin is an adipose tissue-derived adipokine
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