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Merck
CN

D6821

Sigma-Aldrich

盐酸多奈哌齐

≥98% (HPLC)

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别名:
1 H -茚-1-酮,2,3-二氢-5,6-二甲氧基-2-\ [\ [1-(苯甲基)-4-哌啶基] 甲基]-, 盐酸盐, E2020
经验公式(希尔记法):
C24H29NO3 · HCl
分子量:
415.95
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to off-white

溶解性

DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL

储存温度

room temp

SMILES字符串

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl

InChI

1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2

InChI key

HLJIZAKUNCTCQX-UHFFFAOYSA-N

基因信息

human ... ACHE(43)

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应用

用盐酸多奈哌齐进行量效实验,研究其改善尼古丁戒断所致小鼠环境条件反应缺陷的作用。还将其腹腔注射到大鼠体内,研究其改善社会行为缺陷、重复行为和多动的能力。

生化/生理作用

盐酸多奈哌齐一水合物是一种中枢作用的可逆性乙酰胆碱酯酶抑制剂。
盐酸多奈哌齐是一种含有有机化合物和非竞争性抑制剂的哌啶类药物。对治疗阿尔茨海默病(其中痴呆为突出症状)有效。已证实多奈哌齐可诱导认知能力和全身功能。其半衰期为 70 小时。

特点和优势

该化合物收录于受体分类和信号转导手册的乙酰胆碱合成和代谢页面。想要浏览手册的其他页面, 请单击此处

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral - Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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