A1439
垂体腺苷酸环化酶激活多肽-38
别名:
PACAP-38
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关于此项目
经验公式（希尔记法）:
C203H331N63O53S
化学文摘社编号:
分子量:
4534.26
UNSPSC Code:
41106305
NACRES:
NA.32
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
composition
Peptide content, ~70%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... ADCYAP1(116)
General description
垂体腺苷酸环化酶激活多肽38（PACAP38）定位于人类染色体18。27个残基的酰胺化片段（PACAP27）包含另一个同种型。PACAP38是与哺乳动物有关的主要同种型。
Application
垂体腺苷酸环化酶激活多肽38已用于测试其在刺激鸡的环状AMP下丘脑和大脑皮质切片形成中的作用，并在细胞迁移试验（cell migration assay）中处理胶质母细胞瘤细胞（U87MG）以测试其抗侵袭作用。
Biochem/physiol Actions
PACAP-38 是一种与血管活性肠肽 (VIP) 具有高度同源性的神经肽。 据报道，它是一种神经元存活因子。
垂体腺苷酸环化酶激活多肽38（PACAP38）是一种心脏保护剂，可有助于治疗放射诱发心脏病（RIHD）。它在心肌细胞的氧化应激过程中起保护作用。PACAP38具有抗氧化、抗细胞凋亡和抗炎特性。它与偏头痛和丛集性头痛的病理生理学有关。
Other Notes
从0.1％TFA水溶液中冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
A J Martínez-Fuentes et al.
Endocrinology, 139(12), 5116-5124 (1998-12-01)
We have recently shown that the two bioactive forms of pituitary adenylate cyclase-activating polypeptide, PACAP38 and PACAP27, stimulate GH release and GH messenger RNA (mRNA) accumulation in cultured porcine pituitary cells. However, dose- and time-related differences in the response to
E M Lutz et al.
British journal of pharmacology, 128(4), 934-940 (1999-11-11)
1 The VPAC2 and PAC1 receptors are closely related members of the Group II G protein-coupled receptor family. At the VPAC2 receptor, VIP is equipotent to PACAP-38 in stimulating cyclic AMP production, whereas at the PAC1 receptor PACAP-38 is many
Bernadett Tuka et al.
The journal of headache and pain, 17(1), 69-69 (2016-08-01)
Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1439-.1MG | 04061833342343 |