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等级
for molecular biology
质量水平
表单
liquid
组成
iso-ɑ-methylionone, ≥85%
iso-β-methylionone, ≤10%
密度
0.93 g/mL at 20 °C (lit.)
储存温度
room temp
SMILES字符串
CC(=O)C(\C)=C\C1C(C)=CCCC1(C)C
InChI
1S/C14H22O/c1-10-7-6-8-14(4,5)13(10)9-11(2)12(3)15/h7,9,13H,6,8H2,1-5H3/b11-9+
InChI key
JRJBVWJSTHECJK-PKNBQFBNSA-N
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一般描述
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.
应用
Suitable for
- contact sensitization studies to identify allergens present in cosmetic preparations
- elucidation of molecular pathways related to allergic reactions
- analytical standard
危险声明
预防措施声明
危险分类
Aquatic Chronic 2
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
230.5 °F - closed cup
闪点(°C)
110.3 °C - closed cup
个人防护装备
Eyeshields, Gloves
Valerie T Politano et al.
International journal of toxicology, 31(6), 595-601 (2013-01-04)
Alpha-iso-methylionone (AIM), a fragrance ingredient, was evaluated for systemic toxicity in rats. Male and female Sprague Dawley rats were administered 0, 5, 30, or 500 mg/kg/d AIM via gavage for 90 days. Statistically significant changes in blood chemistry parameters (reduced
A Lapczynski et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45 Suppl 1, S280-S289 (2007-11-27)
A toxicologic and dermatologic review of alpha-iso-methylionone when used as a fragrance ingredient is presented.
Valerie T Politano et al.
International journal of toxicology, 26(3), 271-276 (2007-06-15)
Alpha-iso-methylionone, a widely used fragrance ingredient, was evaluated for developmental toxicity in presumed pregnant Sprague-Dawley rats (25/group). Oral dosages of 0, 3, 10, or 30 mg/kg/day alpha-iso-methylionone in corn oil were administered by gavage on gestational days 7 to 17.
Susumu Ishizaki et al.
Bioscience, biotechnology, and biochemistry, 68(5), 1164-1166 (2004-06-01)
The main biodegradation product of (+/-)-alpha-isomethylionone (2) with standard activated sludge was characterized as (+/-)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)propan-2-one (1) by its analysis and synthesis. Both enantiomers (1a and 1b) of 1 were synthesized by starting from (R)- and (S)-2,4,4-trimethyl-2-cyclohexen-1-ol (3a and 3b), respectively.
Susun An et al.
Contact dermatitis, 53(6), 320-323 (2005-12-21)
The purpose of this study is to determine the frequency of responses to selected fragrances in patients with suspected fragrance allergy and to evaluate the risk factors. 9 dermatology departments of university hospitals have participated in this study for the
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