质量水平
检测方案
≥98.0% (HPLC)
形式
powder
旋光性
[α]/D 86.0±2.0°, c = 1 in H2O
甜味
600 × sucrose
颜色
white to off-white
有效pH范围
6-8 (20 °C, 100 g/L)
mp
114.5 °C ((238.1 °F ) - OECD Test Guideline 102)
溶解性
~300 g/L at 25 °C (77 °F)
SMILES字符串
OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl
InChI
1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
InChI key
BAQAVOSOZGMPRM-QBMZZYIRSA-N
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应用
三氯蔗糖是一种无热量糖，用作甜味剂，可激活 T1R2/T1R3 甜味受体，调节胰高血糖素样肽-1、葡萄糖依赖性胰岛素营养肽和肠促胰岛素分泌。
生化/生理作用
一种人类可以检测到的合成甜味剂。可激活肠内分泌细胞上的 T1R2/T1R3 甜味受体，引起胰高血糖素样肽-1 和葡萄糖依赖性胰岛素肽的激素分泌增加。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Nimesh Shukla et al.
Archives of biochemistry and biophysics, 639, 38-43 (2017-12-31)
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress. We have further
Christopher B Forsyth et al.
PloS one, 6(12), e28032-e28032 (2011-12-07)
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves
Ann-Kristin Eriksson Wiklund et al.
Chemosphere, 86(1), 50-55 (2011-10-01)
The non-calorie sweetener sucralose - sucrose containing three chlorine atoms - is intensively sweet and has become a popular substitute for sugar. Its widespread use, exceptional stability in combination with high water solubility have thus resulted in contamination of recipient
Virender K Sharma et al.
Chemosphere, 87(6), 644-648 (2012-02-22)
The kinetics of the oxidation of sucralose, an emerging contaminant, and related monosaccharides and disaccharides by ferrate(VI) (Fe(VI)) were studied as a function of pH (6.5-10.1) at 25°C. Reducing sugars (glucose, fructose, and maltose) reacted faster with Fe(VI) than did
Ana I Domingos et al.
Nature neuroscience, 14(12), 1562-1568 (2011-11-15)
We developed an assay for quantifying the reward value of nutrient and used it to analyze the effects of metabolic state and leptin. In this assay, mice chose between two sippers, one of which dispensed water and was coupled to
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