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60010

Sigma-Aldrich

山柰酚

≥97.0% (HPLC)

别名:

3,4′,5,7-四羟基黄酮, 3,5,7-三羟基-2-（4-羟基苯基）-4 H -1-苯并吡喃-4-酮, 萝卜素

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10 X 1.2 ML
¥736.86

¥736.86

国内现货，预计发货时间2025年4月16日详情

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10 X 1.2 ML
¥736.86

About This Item

经验公式（希尔记法）:
C15H10O6
CAS号:
520-18-3
分子量:
286.24
Beilstein:
304401
MDL编号:
MFCD00016938
UNSPSC代码:
12352205
PubChem化学物质编号:
57651711
NACRES:
NA.47

¥736.86

国内现货，预计发货时间2025年4月16日详情

获取大包装报价

方案

≥97.0% (HPLC)

杂质

≤12% water

应用

metabolomics
vitamins, nutraceuticals, and natural products

SMILES字符串

Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

InChI key

IYRMWMYZSQPJKC-UHFFFAOYSA-N

基因信息

human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , CYP2C9(1559) , GSK3A(2931)
mouse ... Hexa(15211)

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一般描述

山柰酚是一种多酚类抗氧化剂，广泛存在于蔬菜和水果中。[1]它具有二苯基丙烷结构。在许多植物中，它以糖苷形式存在，即山柰酚-3-O-葡糖苷。[2]

应用

山柰酚可用于：
  • 测试其对成骨细胞增殖、迁移及小鼠成骨前细胞系（MC3T3-E1 细胞）中分化的影响[3]
  • 用作玉米烯酮（ZEA）诱导的氧化应激和 HEPG2 细胞中的细胞凋亡的抗氧化剂和肝保护剂[4]
  • 用作一种神经保护剂，以对抗氯化镉（CdCl2）诱导的大鼠海马损伤和记忆缺陷[5]
  • 用作抗炎剂，与芹菜素一起对患有膝关节骨性关节炎的雄性大鼠进行干细胞治疗[6]

锑的显色剂在低 ppm 范围内 ，镓和铟的显色剂在亚 ppm 范围内。

生化/生理作用

山柰酚基于其二苯基丙烷基团而具有疏水性。[2]它具有抗炎作用和抗氧化特性，并且可调节促炎酶的活性。[2]山柰酚是一种化学预防剂，对细胞活性具有保护作用。[1]它可调节与细胞凋亡、血管生成、转移和炎症相关的信号转导途径的几个关键要素。[1]
有效的破骨细胞骨吸收抑制剂。认为该作用归因于山奈酚的抗氧化和雌激素活性。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCN0036
    BCCL7217
    BCCK3585
    BCCH6661
    BCCG0186

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    Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1
    El-kott A F, et al.,
    The Science of the Total Environment, 138832-138832 (2020)
    Firoozeh Estakhri et al.
    The Knee, 27(3), 817-832 (2020-04-28)
    Based on the anti-inflammatory and anti-oxidant properties of kaempferol and apigenin, we hypothesized that co-injection of these phytochemicals would increase the effectiveness of cell therapy in knee osteoarthritic rats. Anterior cruciate ligament transection (ACLT) was used to induce osteoarthritis (OA).
    Kasi Pandima Devi et al.
    Pharmacological research, 99, 1-10 (2015-05-20)
    Inflammation is an important process of human healing response, wherein the tissues respond to injuries induced by many agents including pathogens. It is characterized by pain, redness and heat in the injured tissues. Chronic inflammation seems to be associated with
    Peramaiyan Rajendran et al.
    International journal of molecular sciences, 22(1) (2021-01-01)
    In this study, kaempferol (KFL) shows hepatoprotective activity against zearalenone (ZEA)-induced oxidative stress and its underlying mechanisms in in vitro and in vivo models were investigated. Oxidative stress plays a critical role in the pathophysiology of various hepatic ailments and
    Teresa Tarragó et al.
    Bioorganic & medicinal chemistry, 16(15), 7516-7524 (2008-07-25)
    Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. In a
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    商品

    Dietary Antioxidants

    Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

    膳食抗氧化剂

    抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

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