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Merck
CN
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文件

60010

Sigma-Aldrich

山柰酚

≥97.0% (HPLC)

别名:

3,4′,5,7-四羟基黄酮, 3,5,7-三羟基-2-（4-羟基苯基）-4 H -1-苯并吡喃-4-酮, 萝卜素

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About This Item

经验公式（希尔记法）:
C15H10O6
CAS号:
520-18-3
分子量:
286.24
Beilstein:
304401
MDL编号:
MFCD00016938
UNSPSC代码:
12352205
PubChem化学物质编号:
57651711
NACRES:
NA.47

质量水平

100

检测方案

≥97.0% (HPLC)

杂质

≤12% water

应用

metabolomics
vitamins, nutraceuticals, and natural products

SMILES字符串

Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

InChI key

IYRMWMYZSQPJKC-UHFFFAOYSA-N

基因信息

human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , CYP2C9(1559) , GSK3A(2931)
mouse ... Hexa(15211)

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相关类别

一般描述

山柰酚是一种多酚类抗氧化剂，广泛存在于蔬菜和水果中。它具有二苯基丙烷结构。在许多植物中，它以糖苷形式存在，即山柰酚-3-O-葡糖苷。

应用

山柰酚可用于：
  • 测试其对成骨细胞增殖、迁移及小鼠成骨前细胞系（MC3T3-E1 细胞）中分化的影响
  • 用作玉米烯酮（ZEA）诱导的氧化应激和 HEPG2 细胞中的细胞凋亡的抗氧化剂和肝保护剂
  • 用作一种神经保护剂，以对抗氯化镉（CdCl2）诱导的大鼠海马损伤和记忆缺陷
  • 用作抗炎剂，与芹菜素一起对患有膝关节骨性关节炎的雄性大鼠进行干细胞治疗

锑的显色剂在低 ppm 范围内 ，镓和铟的显色剂在亚 ppm 范围内。

生化/生理作用

山柰酚基于其二苯基丙烷基团而具有疏水性。它具有抗炎作用和抗氧化特性，并且可调节促炎酶的活性。山柰酚是一种化学预防剂，对细胞活性具有保护作用。它可调节与细胞凋亡、血管生成、转移和炎症相关的信号转导途径的几个关键要素。
有效的破骨细胞骨吸收抑制剂。认为该作用归因于山奈酚的抗氧化和雌激素活性。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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