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安全信息

51290

Sigma-Aldrich

血红蛋白 来源于牛血液

lyophilized, 2×cryst., ≥90% (SDS-PAGE), powder

别名:

Hb, 牛血红蛋白, 高铁血红蛋白

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352202

生物来源

bovine blood

质量水平

方案

≥90% (SDS-PAGE)

表单

powder

质量

2×cryst.
lyophilized

分子量

Mr ~64500

技术

UV/Vis spectroscopy: suitable

杂质

salt, none detected
~0.3% Fe

缺失

≤8% loss on drying

储存温度

2-8°C

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一般描述

Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.

应用

α-弹性蛋白的溶解度已被应用于弹性蛋白模拟生物材料的构建。

生化/生理作用

氧气转运蛋白。Fe2+/Fe3+平衡是血液氧合的一种生理指标;脱氧血红蛋白通过将亚硝酸还原为NO来补充反馈回路,而NO是一种可增强血液流向缺氧组织流量的血管扩张剂。
氧转运体,NO 清除剂

注意

由于天然血红蛋白在空气中易于氧化,因此这些制剂主要为高铁血红蛋白。

其他说明

Review: Oxygen carrier proteins
Sales restrictions may apply

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

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Paul W Buehler et al.
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
M. Brunori et al.
Topics in Molecular and Structural Biology, 7, 263-263 (1985)
Mihaela Balu et al.
Biophysical journal, 104(1), 258-267 (2013-01-22)
We employ a clinical multiphoton microscope to monitor in vivo and noninvasively the changes in reduced nicotinamide adenine dinucleotide (NADH) fluorescence of human epidermal cells during arterial occlusion. We correlate these results with measurements of tissue oxy- and deoxyhemoglobin concentration during
Rui Liu et al.
Experimental hematology, 41(7), 656-661 (2013-03-30)
Laser tweezers Raman spectroscopy was used to characterize the oxygenation response of single normal adult, sickle, and cord blood red blood cells (RBCs) to an applied mechanical force. Individual cells were subjected to different forces by varying the laser power
Rebekka Heitmar et al.
Investigative ophthalmology & visual science, 54(4), 2807-2811 (2013-03-16)
To establish the optimal flash settings for retinal vessel oxygen saturation parameters using dual-wavelength imaging in a multiethnic group. Twelve healthy young subjects (mean age 32 years [SD 7]; three Mediterranean, two South Asian, and seven Caucasian individuals) underwent retinal

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