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生物来源
bovine blood
质量水平
方案
≥90% (SDS-PAGE)
表单
powder
质量
2×cryst.
lyophilized
分子量
Mr ~64500
技术
UV/Vis spectroscopy: suitable
杂质
salt, none detected
~0.3% Fe
缺失
≤8% loss on drying
储存温度
2-8°C
基因信息
cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)
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一般描述
Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.
应用
α-弹性蛋白的溶解度已被应用于弹性蛋白模拟生物材料的构建。
生化/生理作用
氧气转运蛋白。Fe2+/Fe3+平衡是血液氧合的一种生理指标;脱氧血红蛋白通过将亚硝酸还原为NO来补充反馈回路,而NO是一种可增强血液流向缺氧组织流量的血管扩张剂。
氧转运体,NO 清除剂
注意
由于天然血红蛋白在空气中易于氧化,因此这些制剂主要为高铁血红蛋白。
其他说明
Review: Oxygen carrier proteins
Sales restrictions may apply
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
Topics in Molecular and Structural Biology, 7, 263-263 (1985)
In vivo multiphoton NADH fluorescence reveals depth-dependent keratinocyte metabolism in human skin.
Biophysical journal, 104(1), 258-267 (2013-01-22)
We employ a clinical multiphoton microscope to monitor in vivo and noninvasively the changes in reduced nicotinamide adenine dinucleotide (NADH) fluorescence of human epidermal cells during arterial occlusion. We correlate these results with measurements of tissue oxy- and deoxyhemoglobin concentration during
Experimental hematology, 41(7), 656-661 (2013-03-30)
Laser tweezers Raman spectroscopy was used to characterize the oxygenation response of single normal adult, sickle, and cord blood red blood cells (RBCs) to an applied mechanical force. Individual cells were subjected to different forces by varying the laser power
Investigative ophthalmology & visual science, 54(4), 2807-2811 (2013-03-16)
To establish the optimal flash settings for retinal vessel oxygen saturation parameters using dual-wavelength imaging in a multiethnic group. Twelve healthy young subjects (mean age 32 years [SD 7]; three Mediterranean, two South Asian, and seven Caucasian individuals) underwent retinal
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