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Merck
CN

47729

N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸

≥99.0% (TLC), BioXtra

别名:

N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸, fMLF, fMLP（用词错误，但已被广泛使用）, 趋化肽

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关于此项目

经验公式（希尔记法）:
C21H31N3O5S
化学文摘社编号:
59880-97-6
分子量:
437.55
NACRES:
NA.26
PubChem Substance ID:
57651094
UNSPSC Code:
12352209
MDL number:
MFCD00036780
Beilstein/REAXYS Number:
2315783

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产品名称

N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸, BioXtra, ≥99.0% (TLC)

InChI

1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

SMILES string

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI key

PRQROPMIIGLWRP-BZSNNMDCSA-N

product line

BioXtra

assay

≥99.0% (TLC)

form

powder

color

white

solubility

DMF: 50 mg/mL, clear, colorless

application(s)

cell analysis

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... FPR1(2357)

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相关类别

Application

1.第4和第5应用无法访问
2.第3应用不相关。

Biochem/physiol Actions

N-甲酰基-Met-Leu-Phe是一种有效的趋化肽和甲酰肽受体（FPR）激动剂，可诱导巨噬细胞的代谢爆发，伴随呼吸四氯、溶酶体酶分泌和超氧阴离子产生的增加。
有效的趋化肽。诱导巨噬细胞的代谢爆发，并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN0534
BCCK3106
BCCH2160
BCCC3535
BCBT6614

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C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
J James B Edelman et al.
Shock (Augusta, Ga.), 39(2), 149-154 (2013-01-18)
Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
Alexandra F Santos et al.
The Journal of allergy and clinical immunology, 134(3), 645-652 (2014-07-30)
Most of the peanut-sensitized children do not have clinical peanut allergy. In equivocal cases, oral food challenges (OFCs) are required. However, OFCs are laborious and not without risk; thus, a test that could accurately diagnose peanut allergy and reduce the
Lunhua Liu et al.
Molecular biology of the cell, 23(24), 4751-4765 (2012-10-26)
Integrin activation is required to facilitate multiple adhesion-dependent functions of neutrophils, such as chemotaxis, which is critical for inflammatory responses to injury and pathogens. However, little is known about the mechanisms that mediate integrin activation in neutrophils. We show that
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