推荐产品
生物来源
mouse
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
MRQ-5, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (420M-14)
vial of 0.5 mL concentrate (420M-15)
bottle of 1.0 mL predilute (420M-17)
vial of 1.0 mL concentrate (420M-16)
bottle of 7.0 mL predilute (420M-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
同位素/亚型
IgG1
控制
lobular breast carcinoma
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
基因信息
human ... CTNND1(1500)
一般描述
p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation. In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology.
质量
 IVD |  IVD |  IVD |  RUO |
联系
p120 Catenin Positive Control Slides, Product No. 420S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A U Jawhari et al.
The Journal of pathology, 189(2), 180-185 (1999-11-05)
p120(ctn) is a substrate of the tyrosine kinase pp60 src. Tyrosine kinases such as src localize to the adherens junctions and phosphorylate junctional proteins in both normal and transformed cells.(1) p120(ctn) forms a complex with E-cadherin at the adherens junction
David I Bellovin et al.
Cancer research, 65(23), 10938-10945 (2005-12-03)
We examined the expression and localization of p120 catenin (p120ctn) as a consequence of the epithelial to mesenchymal transition (EMT) of highly differentiated colon carcinoma cells (LIM1863 cells). This unique line grows in suspension as spheroids and undergoes an EMT
David J Dabbs et al.
The American journal of surgical pathology, 31(3), 427-437 (2007-02-28)
The distinction between lobular and ductal lesions of the breast is important in several circumstances. Diagnostic reproducibility of lobular versus ductal lesions, based on histology alone, is less than optimal. The proper distinction between atypical lobular hyperplasia, lobular carcinoma in
David Sarrió et al.
Oncogene, 23(19), 3272-3283 (2004-04-13)
Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most
A B Reynolds et al.
Molecular and cellular biology, 14(12), 8333-8342 (1994-12-01)
p120cas is a tyrosine kinase substrate implicated in ligand-induced receptor signaling through the epidermal growth factor, platelet-derived growth factor, and colony-stimulating factor receptors and in cell transformation by Src. Here we report that p120 associates with a complex containing E-cadherin
商品
免疫组织化学（免疫组化，IHC）用于表征所有组织中的细胞内蛋白质或各种细胞表面。个体标记，或更常用的各种标记蛋白质组，可用于表征各种肿瘤亚型，确定原发组织，区分转移性肿瘤和原发性肿瘤，并提供可能对预后有重要意义、预测对治疗的响应、或评估残留肿瘤后处理的其他信息。
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