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质量水平
方案
≥95.0% (HPLC)
表单
powder
杂质
≤10.0% water
mp
≥350 °C (lit.)
SMILES字符串
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
基因信息
human ... ESR1(2099) , ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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应用
- 鱼饲料生产中的植物雌激素：香豆雌酚（coumestrol）被用于鱼饲料生产中的生物标志物，有助于评估这些饲料中使用的植物原料 （Pavlopoulos et al., 2023）。
- 考迈斯托醇和大豆叶片衰老: 考察了香豆雌酚（coumestrol）在大豆叶片衰老中的作用，特别是它与植物激素的相互作用，表明了其潜在的农艺效益和在作物科学中的应用，它可作为一种植物抗毒素（Mun et al., 2021）
- 大豆的系统防御本研究考察了香豆雌酚启动（priming ）对大豆防御根腐线虫的影响，强调了其作为天然植物防御增强剂的潜力(Adss et al., 2021）。
生化/生理作用
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Larry M Mallis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 796(1), 71-86 (2003-10-14)
In recent years, consumption of herbal supplements as an alternative to pharmaceutical drug therapy has increased. For example, with the health claims labeling which describes the link between soy-protein and a reduced risk of coronary heart disease (CHD), the consumption
Bickoff, E.M., et al.
Journal of the American Chemical Society, 80, 3969-3969 (1958)
Camila Franco et al.
International journal of pharmaceutics, 369(1-2), 5-11 (2008-11-26)
Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form. In order to improve its solubility in water, coumestrol was associated with beta-cyclodextrin in aqueous media followed by
Suzan L Carmichael et al.
Nutrition journal, 10, 105-105 (2011-10-08)
Phytoestrogens may be associated with a variety of different health outcomes, including outcomes related to reproductive health. Recently published data on phytoestrogen content of a wide range of foods provide an opportunity to improve estimation of dietary phytoestrogen intake. Using
D F Argenta et al.
Die Pharmazie, 66(12), 929-932 (2012-02-09)
A simple, rapid, and sensitive LC method to determine coumestrol incorporated in the lipid nanoemulsions was validated. The analyses were performed at room temperature on a reversed-phase C18 column using a mobile phase composed of methanol/water with 0.1% trifluoracetic acid
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