01905
腺苷 5′-二磷酸
≥95% (HPLC)
别名:
5′-ADP
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关于此项目
经验公式（希尔记法）:
C10H15N5O10P2
化学文摘社编号:
分子量:
427.20
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.55
EC Number:
200-392-5
MDL number:
Beilstein/REAXYS Number:
67722
Assay:
≥95% (HPLC)
Form:
powder
Storage temp.:
−20°C
InChI key
XTWYTFMLZFPYCI-KQYNXXCUSA-N
InChI
1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
assay
≥95% (HPLC)
form
powder
impurities
≤15.0% water (KFT)
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... HSP90AA1(3320), P2RY1(5028)
Application
腺苷-5′-二磷酸（5′-ADP或ADP）被用作研究盐敏感型（DS）和盐抵抗型（DR）Dahl大鼠的内皮依赖性血管反应的测试化合物。本品被用于研究犬血管平滑肌和内皮上的不同P2-嘌呤能受体亚型。
Biochem/physiol Actions
腺苷-5′-二磷酸可诱导人血小板聚集，并且非竞争性阻断人血小板腺苷酸环化酶活化。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Thomas Cuisset et al.
Journal of the American College of Cardiology, 48(7), 1339-1345 (2006-10-03)
We analyzed the benefit of a 600-mg clopidogrel loading dose on platelet reactivity and clinical outcomes after stenting for non-ST-segment elevation acute coronary syndrome (NSTE ACS). High post-treatment platelet reactivity (HPPR = adenosine diphosphate 10 mumol x l(-1) [ADP]-induced platelet
N J Cusack et al.
British journal of pharmacology, 76(1), 221-227 (1982-05-01)
1 Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and noncompetitively inhibits stimulated human platelet adenylate cyclase; it has been suggested that these two effects are mediated by separate ADP receptors on the platelet surface. 2 Adenosine 5'-triphosphate and seven adenine
T F Lüscher et al.
Hypertension (Dallas, Tex. : 1979), 9(2), 157-163 (1987-02-01)
Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high
D A Houston et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 501-506 (1987-05-01)
P2-Purinergic agonists can induce direct contractions in saphenous veins and endothelium-dependent relaxations in coronary arteries of the dog. For contractions, the rank order of agonist potency was alpha, beta-methylene-ATP much greater than ATP greater than ADP. For endothelium-dependent relaxation, the
Yoshihiro Matsumura et al.
The Journal of biological chemistry, 288(43), 31069-31079 (2013-08-31)
The C terminus of Hsp70 interacting protein (CHIP) E3 ligase functions as a key regulator of protein quality control by binding the C-terminal (M/I)EEVD peptide motif of Hsp/c70(90) with its N-terminal tetratricopeptide repeat (TPR) domain and facilitating polyubiquitination of misfolded
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