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Merck
CN

Y0001534

氨磺必利

European Pharmacopoeia (EP) Reference Standard

别名:

氨磺必利

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关于此项目

经验公式（希尔记法）:
C17H27N3O4S
化学文摘社编号:
71675-85-9
分子量:
369.48
NACRES:
NA.24
PubChem Substance ID:
329831479
UNSPSC Code:
41116107
MDL number:
MFCD00866691

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产品名称

氨磺必利, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)

SMILES string

O=C(NCC1CCCN1CC)C2=CC(S(=O)(CC)=O)=C(N)C=C2OC

InChI key

NTJOBXMMWNYJFB-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

amisulpride

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR6(3362), HTR7(3363)

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相关类别

Application

Amisulpride for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Amisulpride is a highly selective D2/D3 dopamine receptor antagonist and atypical antipsychotic.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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F Loy et al.
Oral diseases, 20(8), 796-802 (2013-11-20)
Amisulpride is reported to inhibit clozapine-induced sialorrhea. Preclinically, clozapine evokes muscarinic-M1-type-mediated secretion that, however, amisulpride does not reduce. Instead, amisulpride, without causing any overt secretion per se, enhances both nerve- and autonomimetic-evoked salivation by unknown mechanism(s). Hypothesizing that amisulpride prepares

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