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Merck
CN

T1850000

维甲酸

European Pharmacopoeia (EP) Reference Standard

别名:

视黄酸, ATRA, 全反式维甲酸, 维生素A酸, 维甲酸

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关于此项目

经验公式（希尔记法）:
C20H28O2
化学文摘社编号:
302-79-4
分子量:
300.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329826691
MDL number:
MFCD00001551
Beilstein/REAXYS Number:
2057223

主要文件

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产品名称

维甲酸, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

SMILES string

CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1

InChI key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

tretinoin

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

180-181 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

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相关类别

Application

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。

Biochem/physiol Actions

全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。

General description

本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息，包括SDS和任何产品信息小册子，均根据现行药典制定和发布。更多信息和支持请访问药典颁发机构网站。

维甲酸是一种用于治疗各种皮肤病的药物，如光损伤皮肤、痤疮等。它用作抗衰老产品，也用作白血病的口服药物。

Other Notes

可能适用相应的销售限制。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
Tashtoush BM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3) (2007)
Bogdan Jakiela et al.
American journal of respiratory cell and molecular biology, 51(2), 229-241 (2014-03-05)
Human rhinoviruses (RVs) are a major cause of exacerbations in asthma and other chronic airway diseases. A characteristic feature of asthmatic epithelium is goblet cell metaplasia and mucus hypersecretion. Bronchial epithelium is also an important source of lipid mediators, including
Muriel Rhinn et al.
Development (Cambridge, England), 139(5), 843-858 (2012-02-10)
Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. The distribution and levels of RA in embryonic tissues are tightly controlled by
Joel Villalobos et al.
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