跳转至内容
Merck
CN
所有图片(1)

文件

T176

Supelco

4-羟基他莫西芬

analytical standard, (E) and (Z) isomers (50:50)

别名:

4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚, 4-OHT, 顺/反-4-羟基三苯氧胺

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C26H29NO2
CAS号:
68392-35-8
分子量:
387.51
UNSPSC代码:
41116107
PubChem化学物质编号:
24899989
NACRES:
NA.24

等级

analytical standard

质量水平

200

形式

powder

技术

HPLC: suitable
gas chromatography (GC): suitable

溶解性

ethanol: 20 mg/mL

抗生素抗菌谱

neoplastics

应用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

作用机制

enzyme | inhibits

SMILES字符串

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6

InChI

1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-

InChI key

ZJLDABGSDWXVGE-BDSXMVAQSA-N

基因信息

human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) , IL6(3569)
rat ... Ar(24208) , Esr1(24890) , Esr2(25149)

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

4-羟基他莫昔芬是一种抗雌激素剂，也是他莫昔芬的活性代谢产物之一，通过细胞色素P4502D6（CYP2D6）的羟基化反应形成。他莫昔芬主要用于乳腺癌的激素治疗。

应用

4-羟基他莫昔芬分析标准品可用于以下应用：
  • 通过超高效液相色谱-电喷雾电离串联质谱（UHPLC-ESI-MS/MS）测定干血斑（dried blood spot，DBS）中的他莫昔芬及三种代谢产物)
  • 通过UHPLC-MS/MS同时评估DBS样品中的他莫昔芬、4-羟基他莫昔芬和去甲基他莫昔芬。
  • 开发和确认一种非水相毛细管电泳（NACE）方法，该方法和电容耦合非接触电导检测（C4D）可用于在液液萃取（LLE）后分析乳腺癌患者的人血浆样品中的他莫昔芬及三种主要代谢产物
  • 通过非水相毛细管电泳（NACE）和紫外检测进行人血浆样品的多残留分析以定量测定他莫昔芬及其分解产物
  • 通过LC-ESI-MS/MS检测人血浆样品中的他莫昔芬、西替考马（centchroman）及其分解产物。

生化/生理作用

化疗药物他莫昔芬的代谢物，表现出比母体药物更有效的雌激素激动剂/拮抗剂活性。也具有脂质过氧化的膜内抑制剂的活性。

其他说明

有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Takashi K Ito et al.
PloS one, 9(7), e102186-e102186 (2014-07-25)
Risk factors for atherosclerosis accelerate the senescence of vascular endothelial cells and promote atherogenesis by inducing vascular inflammation. A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation
Michael J Chisamore et al.
PloS one, 4(5), e5624-e5624 (2009-05-23)
The orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) is a member of the nuclear receptor superfamily. It was identified through a search for genes encoding proteins related to estrogen receptor alpha (ERalpha). An endogenous ligand has not been found. Novel
Paolo Cinelli et al.
BMC developmental biology, 8, 57-57 (2008-05-27)
The transcription factor STAT3 is a downstream target of the LIF signalling cascade. LIF signalling or activation is sufficient to maintain embryonic stem (ES) cells in an undifferentiated and pluripotent state. To further investigate the importance of STAT3 in the
Caroline Brossas et al.
The EMBO journal, 39(21), e99520-e99520 (2020-09-17)
Vertebrate genomes replicate according to a precise temporal program strongly correlated with their organization into A/B compartments. Until now, the molecular mechanisms underlying the establishment of early-replicating domains remain largely unknown. We defined two minimal cis-element modules containing a strong
Olga S Koutsopoulos et al.
PloS one, 6(11), e27498-e27498 (2011-11-19)
The large GTPase dynamin 2 is a key player in membrane and cytoskeletal dynamics mutated in centronuclear myopathy (CNM) and Charcot-Marie Tooth (CMT) neuropathy, two discrete dominant neuromuscular disorders affecting skeletal muscle and peripheral nerves respectively. The molecular basis for
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门