等级
pharmaceutical primary standard
API类
sodium valproate
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
[Na+].CCCC(CCC)C([O-])=O
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
基因信息
human ... ALDH5A1(7915)
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警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Pengfei Shi et al.
BMC cancer, 14, 370-370 (2014-06-03)
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of the natural killer group 2D (NKG2D) ligands on tumor cells; however, the mechanisms vary in different tumor types, and the effect
Kristen A Wellmann et al.
Brain research bulletin, 108, 1-9 (2014-08-19)
Prenatal exposure to valproic acid (VPA) alters rodent social interactions in a dose-dependent way: exposure to a high dose of VPA (>500 mg/kg) mid-gestation decreases social interactions whereas a moderate dose of VPA (350 mg/kg) increases peer-directed social behavior. The
Peter Štefánik et al.
Pharmacology, biochemistry, and behavior, 131, 42-50 (2015-02-11)
Autism is a neurodevelopmental disorder characterised by the disruption of social interactions. Autistic animal models play a crucial role in neurophysiologic research on this disorder. One of these models is based on rats that have been prenatally treated with valproic
Péter Pelsőczi et al.
Frontiers in behavioral neuroscience, 13, 295-295 (2020-02-06)
Autism spectrum disorder (ASD) is characterized by impaired socio-communicational function, repetitive and restricted behaviors. Valproic acid (VPA) was reported to increase the prevalence of ASD in humans as a consequence of its use during pregnancy. VPA treatment also induces autistic-like
Qianyun Gao et al.
International immunopharmacology, 83, 106392-106392 (2020-03-18)
The anti-inflammatory effects of sodium valproate (VPA) in vivo and in vitro have been demonstrated in recent studies. The aim of this study was to evaluate whether VPA can suppress inflammation in bovine mammary epithelial cells (BMECs) stimulated by γ-D-glutamyl-meso-diaminopimelic
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