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PHR1768

地塞米松磷酸钠

Name: 地塞米松磷酸钠
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

地塞米松-21-磷酸二钠盐二钠盐

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About This Item

经验公式（希尔记法）:

C₂₂H₂₈FNa₂O₈P

CAS号:

2392-39-4

分子量:

516.40

Beilstein:

6473066

EC 号:

219-243-0

MDL编号:

MFCD00079105

UNSPSC代码:

41116107

PubChem化学物质编号:

329823600

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 108
traceable to Ph. Eur. D0720000
traceable to USP 1177032

API类

dexamethasone

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI key

PLCQGRYPOISRTQ-FCJDYXGNSA-L

基因信息

human ... NR3C1(2908)

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一般描述

Dexamethasone is a glucocorticoid and an anti-inflammatory agent, widely used in ocular inflammatory diseases.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Dexamethasone Sodium Phosphate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using differential pulse polarography technique and high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC1690 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语：

Warning

危险声明

H302,H361d

预防措施声明

P201 - P301 + P312 + P330 - P308 + P313

危险分类

Acute Tox. 4 Oral - Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Trace determination of dexamethasone sodium phosphate in pharmaceutical formulations by differential pulse polarography

Jeyaseelan C and Joshi PA

Analytical and Bioanalytical Chemistry, 373(8), 772-776 (2002)

Simultaneous determination of gatifloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations by HPLC

Sireesha RK, et al.

African Journal of Pharmacy and Pharmacology, 5(17), 1990-1995 (2011)

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice.

Tzu-Chieh Chen et al.

The Journal of biological chemistry, 294(23), 9213-9224 (2019-05-06)

Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for hypertriglyceridemia and hepatic steatosis induced by the synthetic

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地塞米松磷酸钠

Pharmaceutical Secondary Standard; Certified Reference Material

About This Item

属性

等级

质量水平

Agency

API类

CofA

包装

技术

应用

格式

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

分析说明

其他说明

附注

相关产品

相关产品

安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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