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Merck
CN

PHR1700

Supelco

利巴韦林

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

利巴韦林, 1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺

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About This Item

经验公式(希尔记法):
C8H12N4O5
CAS号:
分子量:
244.20
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to BP 593
traceable to Ph. Eur.
traceable to USP 1602706

API类

ribavirin

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

InChI key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

基因信息

human ... IMPDH1(3614)

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一般描述

嘌呤核苷酸生物合成中咪唑核苷酸中间体的类似物。
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

应用

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

用于抵御多种人类病毒感染的抗病毒剂,特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸,是肌苷一磷酸 (IMP) 脱氢酶的抑制剂。
用于抵御多种人类病毒感染的抗病毒剂,特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸,是肌苷一磷酸 (IMP) 脱氢酶的抑制剂,但也有实验证据支持许多其他作用机制。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Muta. 2 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Intravenous ribavirin and hyperammonemia in an immunocompromised patient infected with adenovirus.
Bertrand P, et al.
Pharmacotherapy, 20(10), 1216-1220 (2000)
Stability-Indicating HPLC-DAD Determination of Ribavirin in Capsules and Plasma.
Haggag RS, et al.
Journal of Chromatographic Science, 52(6), 493-500 (2013)

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