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PHR1602

氯沙坦钾

Name: 氯沙坦钾
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氯沙坦钾, 2-丁基-4-氯-1-[[2′-(2H-四唑-5-基)[1,1′-联苯]-4-基]甲基]- 1H-咪唑-5-甲醇钾盐, 2-丁基-4-氯-1-{[2′-(1H-四唑-5-yl)(1,1′-联苯)-4-yl]甲基}-1H-咪唑-5-甲醇单钾盐, DuP 753, MK 954, 钾5-(4′-((2-丁基-4-氯-5-(羟甲基)-1H-咪唑-1-基)甲基)-[1,1′-联苯]-2-yl)四唑-1-ide

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About This Item

经验公式（希尔记法）:

C₂₂H₂₂ClKN₆O

CAS号:

124750-99-8

分子量:

461.00

Beilstein:

5845770

MDL编号:

MFCD02092704

UNSPSC代码:

41116107

PubChem化学物质编号:

329823502

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 867
traceable to Ph. Eur. Y0001062
traceable to USP 1370462

API类

losartan

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChI key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

基因信息

human ... AGTR1(185)

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一般描述

用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
氯沙坦钾是一类新型的口服活性非肽血管紧张素II（AT₁型）受体拮抗剂药物，可用于治疗高血压。凭借高特异性、选择性和耐受性，它具有高于其他肽受体拮抗剂药物和血管紧张素转换酶（ACE）抑制剂的活性。

应用

氯沙坦钾可用作药物参考标准品，通过多种色谱技术和分光光度技术测定药物制剂中的分析物。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

氯沙坦钾是一种口服、强效、选择性的竞争血管紧张素II受体1型 (AT1)拮抗剂。氯沙坦钾用于治疗高血压。

分析说明

这些二级标准品可追溯至USP、EP和BP一级标准品。

其他说明

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

附注

想要查看本品的检验报告示例，请在下框中输入LRAC0141。这只是一个示例证书，可能与您收到的批次不符。

1370495

1370484

1370509

1370510

BP867

氯沙坦钾, British Pharmacopoeia (BP) Reference Standard

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Spectrophotometric and HPLC methods for simultaneous estimation of amlodipine besilate, losartan potassium and hydrochlorothiazide in tablets.

Wankhede SB, et al.

Indian Journal of Pharmaceutical Sciences, 72(1), 136-136 (2010)

Validated RP-HPLC method for simultaneous quantitation of losartan potassium and metolazone in bulk drug and formulation.

Dubey R, et al.

Scientia Pharmaceutica, 79(3), 545-554 (2011)

Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.

Anna D Manis et al.

Clinical science (London, England : 1979), 133(24), 2449-2461 (2019-12-05)

Kir5.1 (encoded by the Kcnj16 gene) is an inwardly rectifying K+ (Kir) channel highly expressed in the aldosterone-sensitive distal nephron of the kidney, where it forms a functional channel with Kir4.1. Kir4.1/Kir5.1 channels are responsible for setting the transepithelial voltage

Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products.

Hertzog DL, et al.

Journal of Pharmaceutical and Biomedical Analysis, 30(3), 747-760 (2002)

Beneficial anti-inflammatory effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in the treatment of dextran sulfate sodium-induced colitis in mice.

H Salmenkari et al.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 69(4) (2018-11-12)

The renin-angiotensin system (RAS) in the intestine is involved in the regulation of inflammation, apoptosis and tissue fibrosis in experimental models of colitis; the inhibition of local RAS by pharmacologic interventions has been claimed to prevent and alleviate colitis. In

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