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PHR1480

Supelco

炔雌醇

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

17α-乙炔基雌二醇, 17α-乙炔基-1,3,5(10)-雌甾三烯-1,17β-二醇, 19-去甲-1,3,5(10),17α-雌甾三烯-20-炔-3,17-二醇, 炔雌醇

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About This Item

经验公式（希尔记法）:
C20H24O2
CAS号:
57-63-6
分子量:
296.40
Beilstein:
2419975
EC 号:
200-342-2
MDL编号:
MFCD00003690
UNSPSC代码:
41116107
PubChem化学物质编号:
329823408
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 421
traceable to Ph. Eur. E1900000
traceable to USP 1260001

API类

ethinyl estradiol

CofA

current certificate can be downloaded

包装

pkg of 200 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

182-183 °C (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

基因信息

human ... ESR1(2099)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Ethinyl Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB9196 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography.
Strusiak SH, et al.
Journal of Pharmaceutical Sciences, 71(6), 636-640 (1982)
Quantitative analysis of ethynodiol diacetate and ethinyl estradiol/mestranol in oral contraceptive tablets by high?performance liquid chromatography.
Carignan G, et al.
Journal of Pharmaceutical Sciences, 71(2), 264-266 (1982)
Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references.
Ekhato I, et al.
Steroids, 67(3-4), 165-174 (2002)
Simultaneous Determination of Gestodene and Ethinyl Estradiol in Contraceptive Formulations by RP?HPLC.
Laban A, et al.
Analytical Letters, 37(2), 273-282 (2004)
Lisa Baumann et al.
Toxicology and applied pharmacology, 278(3), 230-237 (2014-05-17)
The aim of the present study was to investigate the persistence of the feminizing effects of discontinued 17α-ethinylestradiol (EE2) exposure on zebrafish (Danio rerio). An exposure scenario covering the sensitive phase of sexual differentiation, as well as final gonad maturation
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