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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to BP 277
traceable to Ph. Eur. P0270000
traceable to USP 1496008
API类
papaverine
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
food and beverages
pharmaceutical (small molecule)
格式
neat
储存温度
2-30°C
SMILES字符串
COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
InChI
1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChI key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
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一般描述
Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Simultaneous determination of dipyrone and papaverine in pharmaceutical formulation using PLS regression and UV spectrophotometry
do Nascimento AP, et al.
Analytical Letters, 40(5), 975-986 (2007)
The effect of intravenous papaverine hydrochloride on the cerebral circulation
Jayne H W, et al
The Journal of Clinical Investigation, 31(1), 111-114 (1952)
Alaa El-Gindy
Farmaco (Societa chimica italiana : 1989), 60(9), 745-753 (2005-07-19)
Three methods are developed for the simultaneous determination of diprophylline (DP), phenobarbitone (PH) and papaverine hydrochloride (PP). The chromatographic method depends on a high performance liquid chromatographic (HPLC) separation on a reversed-phase C18 column with a mobile phase consisting of
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
Abdel-Ghani NT, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(2), 373-378 (2002)
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
Boberi B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 15-22 (1999)
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