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文件

PHR1055

法莫替丁

Name: 法莫替丁
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

N′-（氨基磺酰基）-3-([2-（二氨基亚甲基氨基）-4-噻唑基]甲硫基)丙脒

经验公式（希尔记法）:

C₈H₁₅N₇O₂S₃

CAS号:

76824-35-6

分子量:

337.45

MDL编号:

MFCD00079297

UNSPSC代码:

41116107

PubChem化学物质编号:

329823085

NACRES:

NA.24

推荐产品

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Sigma-Aldrich

F6889

法莫替丁

USP

1269200

法莫替丁

F0005000

法莫替丁

BP653

法莫替丁

Supelco

PHR1008

维生素C

Supelco

PHR2908

Famotidine Related Compound F

Supelco

PHR1010

羟苯丙酯

Supelco

PHR2910

Famotidine Related Compound C

Sigma-Aldrich

R101

雷尼替丁盐酸盐

Supelco

PHR1012

对羟基苯甲酸甲酯

生物来源

synthetic

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

Agency

BP
EP
USP
traceable to BP 653
traceable to Ph. Eur. F0050000
traceable to USP 1269200

蒸汽压

<0.0000001 kPa ( 25 °C)

API类

famotidine

CofA

current certificate can be downloaded

包装

pkg of 1 g

储存条件

protect from light (20 mm aluminium crimp seal for unused portion)

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white to pale yellow-white

mp

325.4-327.2 °F (163—164°C)

溶解性

DMF: freely soluble
acetone: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
ethyl acetate: practically insoluble
glacial acetic acid: freely soluble
methanol: slightly soluble
water: very slightly soluble

应用

pharmaceutical (small molecule)

格式

neat

运输

ambient

储存温度

2-8°C

SMILES字符串

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

基因信息

human ... HRH2(3274)

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一般描述

Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Famotidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

H₂组胺受体拮抗剂；抗溃疡剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA7133 in the slot below. This is an example certificate only and may not be the lot that you receive.

1269243

1269265

1269221

1269232

1269254

BP653

法莫替丁, British Pharmacopoeia (BP) Reference Standard

PHR2908

PHR2909

PHR2910

Famotidine Related Compound C

PHR2911

Famotidine Related Compound D

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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GC Determination of famotidine, ranitidine, cimetidine, and metformin in pharmaceutical preparations and serum using methylglyoxal as derivatizing reagent

Majidano AS, et al.

Chromatographia, 75(21-22), 1311-1317 (2012)

The

Profiles of Drug Substances, Excipients, and Related Methodology (2011)

Reduction in radiation-induced lymphocytopenia by famotidine in patients undergoing radiotherapy for prostate cancer.

Abolfazl Razzaghdoust et al.

The Prostate, 74(1), 41-47 (2013-09-11)

Ionizing radiation causes a series of hematological alterations especially profound lymphocytopenia during and after the radiotherapy course. To investigate whether famotidine can reduce hematologic toxicity in patients treated with radiotherapy for prostate cancer. A total of 36 patients undergoing radiotherapy

Electrospun formulations containing crystalline active pharmaceutical ingredients.

Blair Kathryn Brettmann et al.

Pharmaceutical research, 30(1), 238-246 (2012-08-28)

To investigate the use of electrospinning for forming solid dispersions containing crystalline active pharmaceutical ingredients (API) and understand the relevant properties of the resulting materials. Free surface electrospinning was used to prepare nanofiber mats of poly(vinyl pyrrolidone) (PVP) and crystalline

High-performance thin-layer chromatography for the determination of ranitidine hydrochloride and famotidine in pharmaceuticals.

Novakovic J.

Journal of Chromatography A, 846(1-2), 193-198 (1999)

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文件

法莫替丁

Pharmaceutical Secondary Standard; Certified Reference Material

推荐产品

属性

生物来源

质量水平

等级

Agency

蒸汽压

API类

CofA

包装

储存条件

技术

颜色

mp

溶解性

应用

格式

运输

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

生化/生理作用

分析说明

其他说明

附注

相关产品

相关产品

安全信息

WGK

闪点(°F)

闪点(°C)

文件

分析证书(COA)

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