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PHR1004

Supelco

布洛芬

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

IB, IBU, α-甲基-4-(异丁基)苯乙酸, (±)-2-(4-异丁基苯基)丙酸

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About This Item

经验公式（希尔记法）:
C13H18O2
CAS号:
15687-27-1
分子量:
206.28
EC 号:
239-784-6
MDL编号:
MFCD00010393
UNSPSC代码:
41116107
PubChem化学物质编号:
329823035
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 539
traceable to Ph. Eur. I0020000
traceable to USP 1335508

API类

ibuprofen

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

基因信息

human ... PTGS1(5742) , PTGS2(5743)

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相关类别

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
布洛芬是取代的芳基丙酸，用作非甾体抗炎药物（NSAID）。

应用

使用高效液相色谱法 (HPLC) 定量测定人血浆样本中的布洛芬时，可使用布洛芬作为标准品。也可用作采用液相色谱法 (LC) 测定犬血浆中布洛芬的参比标准品。
布洛芬可作为药物参考标准品，通过分光光度法 和色谱技术测定药物制剂中的分析物。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的抑制活性大于对 COX-2 的抑制活性。
环氧合酶（COX）抑制剂对 COX-1 的活性高于对 COX-2 的活性。

分析说明

这些二级标准品可多次溯源至美国药典、欧洲药典和英国药典一级标准品（如可用）。

其他说明

该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

若要查看此材料的分析证书示例，请在下面的区域中输入LRAC0253。这只是一个示例证书，可能与您收到批次的产品无关。

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象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H319,H335

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number

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Determination of ibuprofen in human plasma by high-performance liquid chromatography
Litowitz H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 311, 443-448 (1984)
Simultaneous determination of caffeine, paracetamol, and ibuprofen in pharmaceutical formulations by high-performance liquid chromatography with UV detection and by capillary electrophoresis with conductivity detection
Cunha RR, et al.
Journal of Separation Science, 38(10), 1657-1662 (2015)
Spectrofluorometric determination of ibuprofen in pharmaceutical formulations
Damiani PC, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(3-4), 679-683 (2001)
Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HPMC) using HPLC and evaporative light scattering detection
Whelan MR, et al.
Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1355-1359 (2002)
Determination of ibuprofen in dog plasma by liquid chromatography and application in pharmacokinetic studies of an ibuprofen prodrug in dogs
Wang P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38, 714-719 (2005)
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