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N7004

β-烟酰胺腺嘌呤二核苷酸水合物

Name: β-烟酰胺腺嘌呤二核苷酸 水合物
Brand: SIAL

≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

别名:

β-DPN, β-NAD, DPN, NAD, 二磷酸吡啶核苷酸, 辅酶, 辅酶 1, 辅酶 A

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About This Item

经验公式（希尔记法）:

C₂₁H₂₇N₇O₁₄P₂ · xH₂O

CAS号:

53-84-9

分子量:

663.43 (anhydrous basis)

MDL编号:

MFCD00036253

UNSPSC代码:

41106305

eCl@ss:

39200202

PubChem化学物质编号:

24897803

NACRES:

NA.55

生物来源

yeast

质量水平

300

检测方案

≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)

形式

powder

环保替代产品得分

old score: 56
new score: 20
Find out more about DOZN™ Scoring

环保替代产品特性

Waste Prevention
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Design for Energy Efficiency
Use of Renewable Feedstocks
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

颜色

white to off-white

应用

metabolomics

环保替代产品分类

Re-engineered,

储存温度

−20°C

SMILES字符串

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

基因信息

human ... ESR1(2099) , ESR2(2100)

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一般描述

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“防止废弃物”、“危险性较小的化学合成”、“更安全的溶剂和助剂”、“使用可再生原料”和“本质更安全的化学成分，以预防事故”绿色化学原则方面取得了重大改进。点击此处查看其 DOZN 记分卡。

烟酰胺腺嘌呤二核苷酸(NAD)是一种必需的辅酶，这一特性令其超越“电子载体”的传统角色，影响各种细胞过程。在细胞生物学中，NAD 是电子传递链中的关键电子受体，促使细胞′的主要能源ATP的生成。这种电子流动维持了基本的细胞维护和复杂信号传导途径。除了能量方面的作用以外，NAD 可用作动态信号传导分子，控制了细胞对多种刺激的反应。NAD浓度的变动会引发DNA修复、基因表达和细胞死亡中的事件，使得细胞适应应激并维持稳态。

在生物化学研究中，NAD 是sirtuins、多聚ADP核糖聚合酶和cADP核糖合成酶等酶所必需的辅酶。这些酶的催化活性依赖于NAD+，它们影响多个过程，如蛋白质脱乙酰、DNA修复和细胞信号传导。在代谢组学中，NAD在代谢途径中起到关键作用，这一点令其成为全面理解细胞代谢的关键焦点。NAD 参与其它复杂细胞过程，可作为ADP-核糖基化的底物—，核糖基化是影响蛋白质功能的翻译后修饰。它也可作为环ADP核糖的前体，环ADP核糖是涉及钙动员 (calcium mobilization)和细胞通讯的第二信使分子。NAD研究为多个领域（包括老化）带来希望，目前研究人员在积极进行老化研究。研究也探索了它对神经退行性疾病和代谢失调的影响。

应用

β-烟酰胺腺嘌呤二核苷酸水化物已用于：

制备用于NAD+代谢组学研究的 NAD+ 标准溶液
作为MurI 测定反应部分混合物的成分用于谷氨酸消旋酶反应
作为显色染色液的成分用于斑马鱼胚胎的染色

生化/生理作用

电子受体

特点和优势

用途广泛，适用于各种实验室和研究应用。

包装

根据固体质量包装。

制备说明

配制溶液时可能有必要进行温和加热和超声处理。

其他说明

本品是普通型 NAD。

如需了解生化试剂系列的更多信息，请填写此表。

可比产品

产品编号

说明

价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number

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β-烟酰胺腺嘌呤二核苷酸 水合物