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Merck
CN

H3393

Sigma-Aldrich

肝素 钠盐 来源于猪肠粘膜

Grade I-A, ≥180 USP units/mg

别名:

肝素钠

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352201
NACRES:
NA.21

生物来源

Porcine intestinal mucosa

质量水平

类型

Grade I-A

形式

powder

比活

≥180 USP units/mg

颜色

beige

有效pH范围

5.0 - 7.5

溶解性

H2O: 50 mg/mL, clear, colorless to faintly yellow

应用

clinical research
diagnostic assay manufacturing
life science and biopharma

储存温度

room temp

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一般描述

肝素是一种糖胺聚糖 (GAG),属于粘多糖家族,以其有效的抗凝特性而闻名。这种广泛硫酸化的多糖由通过糖苷键连接的 D-葡萄糖胺和己糖醛酸组成。它广泛应用于各类生化研究和细胞培养研究。

应用

培养基中加入猪肠粘膜来源的肝素钠盐,用于精子对卵母细胞的授精猪肠粘膜来源的肝素钠盐可用于:
  • 检查肝素对 FGF21(成纤维细胞生长因子 21)信号传导的影响。
  • 对小鼠脑切片进行免疫染色
  • 定量金鲷(Sparus aurata)血液样本中的白细胞和红细胞
  • 用于抗凝和严重急性呼吸综合征冠状病毒 2 (SARS-CoV2) 抑制测定

生化/生理作用

肝素主要负责延迟血液凝固。它可增强抗凝血酶介导的蛋白酶失活。

肝素在肥大细胞和组胺等介质中合成,与过敏和炎症活动相关。肝素对静脉血栓和肺栓塞表现出治疗作用,有助于预防溶栓后的再血栓形成,并可控制急性心肌梗塞患者的动脉血栓形成。肝素在许多炎症性疾病中表现出抗炎作用,如烧伤、支气管哮喘和溃疡性结肠炎。

其他说明

为了全面了解我们针对客户研究提供的各种多糖产品,建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息,请填写此表
肝素溶液不可高压灭菌,因为高温下可能会发生额外的糖交联。它也不可冻结。

推荐产品

用于诊断制造的肝素产品编号为 SRE0027

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact 客户支持

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  1. What is the molecular weight of Heparin sodium salt?

    Heparin is a mixture of polyanion chains having molecular weights ranging from 6,000 to 30,000 Daltons, with most chains in the range of 17,000 to 19,000 Daltons.

  2. How much Heparin sodium salt, is used to prevent coagulation?

    We suggest using 20 to 50 units per mL of blood.

  3. What is the best way to sterilize Heparin sodium salt?

    Although solutions may be autoclaved at 121 °C for 5 to 10 minutes, we generally recommend sterile filtration. This is because prolonged autoclaving may have an effect on its activity.  

  4. What concentration of Heparin sodium salt, can I use to inhibit RNAse activity?

    Heparin has been used at concentrations ranging from 100 to 500 μg/mL. This has been reported in the J. Biol. Chem., 248, 2095 (1973).

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Xu J et al.
American Journal of Physiology. Endocrinology and Metabolism, 297, E1105-E1105 (2009)
Novel drug development opportunities for heparin
Lever R and Page C P
Nature Reviews Drug Discovery, 1(2) , 140-148 (2002)
Dietary aflatoxin B1 (AFB1) reduces growth performance, impacting growth axis, metabolism, and tissue integrity in juvenile gilthead sea bream (Sparus aurata)
Barany A, et al.
Journal of Separation Science, 533 , 736189-736189 (2021)
L Peter Sarin et al.
Nucleic acids research, 37(4), 1182-1192 (2009-01-09)
The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3' terminus of the template and position it
The anti-inflammatory effects of heparin and related compounds
Young E, et al.
Thrombosis Research, 122(6) , 743-752 (2008)

商品

有五种已发现的糖胺聚糖链(参见图1)透明质酸不是硫酸化的,但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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