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关于此项目
经验公式（希尔记法）:
C18H19NO4Cl2
化学文摘社编号:
分子量:
384.25
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
SMILES string
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI key
RZTAMFZIAATZDJ-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
felodipine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Felodipine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
L-type calcium channel blocker
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
T O Morgan
Journal of cardiovascular pharmacology, 15 Suppl 4, S76-S84 (1990-01-01)
Felodipine is a dihydropyridine that blocks the slow entry channel for calcium. It is highly vascular selective and reduces blood pressure (BP) by dilatation of peripheral arterioles. It reduces BP in mild, moderate, and severe hypertension, and the fall in
Sayantan Chattoraj et al.
Journal of pharmaceutical sciences, 103(12), 3950-3957 (2014-10-30)
The nonisothermal crystallization kinetics of amorphous materials is routinely analyzed by statistically fitting the crystallization data to kinetic models. In this work, we systematically evaluate how the model-dependent crystallization kinetics is impacted by variations in the heating rate and the
A R Lorimer et al.
Journal of cardiovascular pharmacology, 15 Suppl 4, S85-S89 (1990-01-01)
Hypertensive patients, particularly the elderly, may often suffer from other diseases. Therefore, antihypertensive compounds should not negatively affect such disorders. Felodipine is a calcium antagonist that has potentially beneficial effects in angina pectoris and congestive heart failure. Further, it does
P H Dunselman et al.
Clinical pharmacokinetics, 21(6), 418-430 (1991-12-01)
Absorption of felodipine is rapid and complete. A pronounced first-pass metabolism results in a bioavailability of 15%, irrespective of the oral formulation used. The peak plasma concentrations and area under the plasma concentration-time curve are linearly related to the dose.
J L Reid
Journal of cardiovascular pharmacology, 15 Suppl 4, S50-S56 (1990-01-01)
Calcium antagonists demonstrate a close relationship between plasma drug level and effect on blood pressure (BP). Thus, the intensity and duration of action can be influenced by dose and disposition. Felodipine has a dose-related effect on diastolic BP whether given
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