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E3876

Sigma-Aldrich

N -乙基马来酰亚胺

crystalline, ≥98% (HPLC)

别名:

NEM

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About This Item

经验公式（希尔记法）:
C6H7NO2
CAS号:
128-53-0
分子量:
125.13
Beilstein:
112448
EC 号:
204-892-4
MDL编号:
MFCD00005509
UNSPSC代码:
12352106
PubChem化学物质编号:
24278420
NACRES:
NA.21

生物来源

synthetic (organic)

质量水平

200

方案

≥98% (HPLC)

表单

crystalline

储存条件

(Tightly closed. Dry. Keep in a well-ventilated place. )

技术

activity assay: suitable
co-immunoprecipitation (co-IP): suitable
immunoblotting: suitable

颜色

white to faint yellow

沸点

210 °C (lit.)

mp

43-46 °C (lit.)

溶解性

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan

适用性

suitable for Western blot

应用

life science and biopharma

储存温度

2-8°C

SMILES字符串

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

基因信息

human ... KCNQ2(3785) , KCNQ4(9132) , KCNQ5(56479) , SLC6A3(6531) , SLC6A4(6532)

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应用

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。
增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。

制备说明

NEM 以 50mg/ml 的浓度溶于乙醇可得到透明的溶液。NEM 可溶于水（在 4ml 水中的溶解量 >50mg）；然而，水溶液却不稳定。水解速率为假一级，并显著依赖于 pH 值。

其他说明

如需了解生化试剂系列的更多信息，请填写此表。

象形图

Skull and crossbonesCorrosion
GHS06,GHS05

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

163.2 °F - closed cup

闪点(°C)

72.9 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
0000414831
0000414831
0000407415
0000407415
0000391608

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Hannah E Boycott et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), E3955-E3964 (2013-09-26)
Atrial myocytes are continuously exposed to mechanical forces including shear stress. However, in atrial myocytes, the effects of shear stress are poorly understood, particularly with respect to its effect on ion channel function. Here, we report that shear stress activated
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